176375-41-0

Basic information

• Product Name: METHYL 4-(4-FORMYL-2-METHOXYPHENOXY)BUTANOATE
• Synonyms: METHYL 4-(4-FORMYL-2-METHOXYPHENOXY)BUTANOATE;4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester
• CAS NO: 176375-41-0
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.26314
• Mol File: 176375-41-0.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL 4-(4-FORMYL-2-METHOXYPHENOXY)BUTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-(4-FORMYL-2-METHOXYPHENOXY)BUTANOATE(176375-41-0)
• EPA Substance Registry System: METHYL 4-(4-FORMYL-2-METHOXYPHENOXY)BUTANOATE(176375-41-0)

Safety Data

• Hazardous Substances Data: 176375-41-0(Hazardous Substances Data)

Upstream product

• 4897-84-1 Methyl 4-bromobutyrate 
• 121-33-5 vanillin 
• 3153-37-5 methyl 4-chlorobutyrate 

Downstream Products

• 1402231-69-9 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate 
• 1402231-61-1 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoic acid 
• 1402231-71-3 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)-N-(3-(triethoxysilyl)propyl)butanamide 

Relevant articles and documents

Facile synthesis of a o-nitrobenzyl photolabile linker for combinatorial chemistry

Two facile syntheses are described of the o-nitrobenzyl alcohol photolabile linker (5). This compound is a valuable intermediate in the preparation of combinatorial libraries, where it allows release from the solid support to give libraries of acids.

POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS

The invention relates to a compound of formula (I): or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; wherein the fused ring moiety is a non-alkylating moiety; and wherein the compounds are useful as medicaments, in particular for use as a drug in an antibody-drug conjugate and in the treatment of a proliferative disease, a bacterial infection, a malarial infection and inflammation.

In water alkylation of amines with alcohols through a borrowing hydrogen process catalysed by ruthenium nanoparticles

A simple and environmentally benign procedure for the synthesis of secondary amines in water has been developed. Combining Ru3(CO)12, tetraphenylcyclopentadienone and a small quantity of TGPS-750-M surfactant, primary and secondary alcohols were alkylated at N employing equimolar amounts of aromatic amines in water. The reaction occurs under microwave (MW) dielectric heating with high conversion and high yield. When required, the use of biomass-derived 2-MeTHF or GVL as a co-solvent is possible. Under the influence of MWs, a Ru nanoparticle-nanomicelle combination was formed acting as an effective and recyclable catalyst. This protocol was also employed for "in water" cyclisation to synthesise biologically relevant pyrrolobenzodiazepines (PBDs).