176383-21-4Relevant articles and documents
High-throughput preparation of alkyl 4-aryl substituted-2-methyl-6-thioxo- 1,4,5,6-tetrahydropyridine-3-carboxylates under microwave irradiation
Rodriguez, Hortensia,Coro, Julieta,Lam, Anabel,Salfran, Esperanza,Rodriguez-Salarichs, Javier,Suarez, Margarita,Albericio, Fernando,Martin, Nazario
experimental part, p. 125 - 141 (2011/08/07)
An efficient high-throughput synthesis of 4-aryl substituted 1,4,5,6-tetrahydro-2-methyl-6-thioxopyridine-3-carboxylates 5a-p was developed by using Lawesson's reagent, a very effective thionating reagent for carbonyl compounds, under conventional conditi
Novel hexahydrofuro[3,4-b]-2(1H)-pyridones from 4-aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones
Morales, Alhmed,Ochoa, Estael,Suarez, Margarita,Verdecia, Yamila,Gonzalez, Leandro,Martin, Nazario,Quinteiro, Margarita,Seoane, Carlos,Soto, Jose L.
, p. 103 - 107 (2007/10/03)
The title compounds 6 have been prepared in a one-step procedure from the corresponding 4-aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones 4 in good yields. Quantum chemical calculations reveal a non-planar molecule with a distorted dihydropyridone ring and two favoured conformations. The 13C nmr data and theoretical calculations support a strong push-pull effect on the olefinic moiety.
