17640-03-8

Basic information

• Product Name: ethyl 2,2-dichloropropanoate
• Synonyms: 241-625-0; propanoic acid, 2,2-dichloro-, ethyl ester
• CAS NO: 17640-03-8
• Molecular Formula: C₅H₈Cl₂O₂
• Molecular Weight: 171.0218
• EINECS: 241-625-0
• Mol File: 17640-03-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 166.8°C at 760 mmHg
• Flash Point: 60.1°C
• Density: 1.244g/cm³
• Vapor Pressure: 1.75mmHg at 25°C
• Refractive Index: 1.446
• CAS DataBase Reference: ethyl 2,2-dichloropropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,2-dichloropropanoate(17640-03-8)
• EPA Substance Registry System: ethyl 2,2-dichloropropanoate(17640-03-8)

Safety Data

• Hazardous Substances Data: 17640-03-8(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 30362-74-4 tris-(1,1-dichloro-ethyl)-[1,3,5]triazine 
• 535-15-9 ethyl 1,1-dichloroacetate 
• 74-88-4 methyl iodide 
• 19784-30-6 [2,2-Dichloro-1-ethoxy-prop-(Z)-ylidene]-phosphoramidic acid diethyl ester 
• 515-84-4 Ethyl trichloroacetate 
• 17166-16-4 phosphorous acid tetramethyldiamide methylester 
• 75-99-0 2,2-Dichloropropionic acid 
• 594-40-1 2,2-dichloropropionitrile 

Downstream Products

• 940-31-8 2-phenoxypropionic acid 
• 127-17-3 2-oxo-propionic acid 
• 145-13-1 Pregnenolone 
• 72284-20-9 cyclohexyl-3 methyl-2 propene-2 oate d'ethyle 
• 28781-85-3 ethyl 2,2-difluoropropanoate 
• 18240-53-4 2,2-dichloropropanamide 

Relevant articles and documents

The first sequential reaction promoted by manganese: Complete stereoselective synthesis of (E)-α,β-unsaturated esters from 2,2-dichloroesters and aldehydes

(Chemical Equation Presented) α,β-Unsaturated esters were obtained with complete control of stereoselectivity utilizing a sequential reaction of dichloroesters with a variety of aldehydes, promoted by active manganese. This methodology is generally applicable, and the C-C double bond can be di- or trisubstituted. A mechanism based on a successive aldol-type reaction/β-elimination is proposed to explain these results.