176434-13-2Relevant academic research and scientific papers
Colloid and nanodimensional catalysts in organic synthesis: III. Alkylation of amines with primary alcohols catalyzed by colloidal nickel and cobalt
Popov,Mokhov,Tankabekyan
, p. 826 - 830 (2014)
Alkylation of primary amines with primary alcohols has been performed under catalysis by colloidal nickel and cobalt particles. The synthesis of the catalyst and alkylation of amines have been carried out in a one-pot mode. The alkylation at 160-180°C in 6-12 h yields 55-90% of secondary amines.
Nickel-Catalyzed Reduction of Secondary and Tertiary Amides
Simmons, Bryan J.,Hoffmann, Marie,Hwang, Jaeyeon,Jackl, Moritz K.,Garg, Neil K.
supporting information, p. 1910 - 1913 (2017/04/11)
The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant α-deuterated amines.
