176438-29-2

Upstream product

• 176438-26-9 2,3-dihydro-3-(2-hydroxyethyl)-5-phenyl-1,3-oxazin-4-one 
• 6269-99-4 N-(2-hydroxyethyl)-2-phenylacetamide 
• 176438-21-4 1-Oxazolidin-3-yl-2-phenyl-ethanone 

Relevant academic research and scientific papers

First synthetic method for the preparation of 6-unsubstituted-2,3-dihydro-1,3-oxazin-4-ones

The first synthetic pathway to synthesize 6-unsubstituted-2,3-dihydro-1,3-oxazin-4-ones is described. The α-formylation of the starting amide and the cyclization of the α-formylamide with a desired aldehyde under acidic conditions gave compounds 5a-h (R = nPr, iPr, cPr, cHex, Ph, CH2Ph, nHex, and R1 = H, Me). This strategy was used with little modification for the preparation of new monocyclic organic nitrates such as 2a-c (2a (R = Ph, R1 = H, and R2 = H), 2b (R = Ph, R1 = H, and R2 = Me), and 2c ( R = H, R1 = Ph, and R2 = H).