17645-30-6Relevant articles and documents
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Hromatka,Eiles
, p. 129,135 (1948)
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Synthesis of 2,3-dihydroxy-3-(N-substituted carbamoyl)propylphosphonic acid derivatives as hybrid DOXP-fosmidomycin analogues
Blatch, Gregory L.,Kaye, Perry T.,Klein, Rosalyn,Lobb, Kevin A.,Mutorwa, Marius K.
, (2022/02/05)
A six-step synthetic pathway has been established to access a series of racemic 2,3-dihydroxy-3-(N-substituted carbamoyl)propylphosphonic acid derivatives, designed to contain structural features common to both the natural substrate 1-deoxy-D-xylulose 5-p
Useful four-carbon synthons en route to monastrol analogs
Abdou, Amr M.,Botros,Hassan, Rasha A.,Kamel, Mona M.,Taber, Douglass F.,Taher, Azza T.
, p. 139 - 146 (2015/02/18)
A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI 60 cell line panel.