17649-34-2

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 141-97-9 ethyl acetoacetate 
• 56-04-2 2-mercapto-6-methylpyrimidin-4(3H)-one 
• 56-04-2 6-methyl-2-thiouracil 
• 7436-90-0 2,2-dibromostyrene 
• 532-27-4 1-chloroacetophenone 
• 17649-31-9 6-methyl-2-[(2-oxo-2-phenylethyl)thio]pyrimidin-4(3H)-one 

Downstream Products

• 119730-71-1 3-(4-nitrophenyl)-7-methyl-5H-thiazolo<3,2-a>pyrimidin-5-one 
• 1436462-33-7 6-amino-3-(4-aminophenyl)-7-methyl-5H-[1,3]-thiazolo[3,2-a]pyrimidin-5-one 
• 1436462-32-6 7-methyl-6-nitro-3-(4-nitrophenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one 

Relevant academic research and scientific papers

Synthesis of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives

The reaction of 2-aminothiazoles with ethyl acetoacetate in acetic or polyphosphoric acid gave a series of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives which were nitrated with a mixture of nitric and sulfuric acid to 6-nitro-5H-[1,3]thiazolo[3,2-a]

Synthesis and biological evaluation of substituted thiazolamines, imidazo [2,1b] thiazol-6-(5h)-ones, thiazolo [3,2-a] pyrimidin-5-ones and thiazolyl thioureas

Substituted phenyl thiazole-2-amines (TA1-4) when refluxed with ethyl acetoacetate using phosphorous oxychloride and poly phosphoric acid as a catalyst yielded thiazolo-pyrimidines (TP1-4) and with chloroacetic acid in ethanol furnished imidazol-thiazoles (IT1-4). Thiazolyl thioureas (TT1-4) were synthesized by the reaction of TA 1-4 with ammonium thiocynate in dilute hydrochloric acid. The structures of the synthesized compounds have been established on the basis of their spectral data and drug likeliness was analyzed using Molinspiration online resource. The in vitro tuberculostatic potential was evaluated against H 37Rv strain of Mycobacterium tuberculosis by REMA assay and showed moderate activity for compound IT3 Synthesized compounds were also screened against Staphylococcus aureus (MTCC 3160), Bacillus subtilis (MTCC 441), Escherichia coli (MTCC 40) and Pseudomonus aeruginosa (MTC 424) bacteria and showed significant activity.

Synthesis and biological evaluation of substituted thiazolamine, imidazo [2,1-b] thiazol-6(5H)-one, thiazolo [3,2-a] pyrimidin-5-one and thiazolyl thiourea derivatives

Substituted phenyl thiazole-2-amines (TA1-4) refluxed with ethyl acetoacetate using phosphorus oxychloride and polyphosphoric acid as a catalyst yielded thiazolo- pyrimidines (TP1-4) and with chloroacetic acid in ethanol furnished imizado- Thiazolos (IT1-4). Thiazolyl thioreas (TT1-4) were synthesized by the reaction of TA1-4 with ammonium thiocynate in dil hydrochloric acid. The structures of the synthesized compounds have been established on the basis of their spectral data and drug likelines was analyzed using Molinspiration online resource. The in vitro tuberculostatic potential evaluated against H37Rv strain of Mycobacterium tuberculosis by REMA assay has shown moderate activity for compound IT2. Synthesized compounds were screened against Staphylococcus aureus (MTCC 3160), Bacillus subtilis (MTCC 441), Escherichia coli (MTCC 40) and Pseudomonus aeruginosa (MTCC 424) bacteria and have shown significant activity.

Copper-catalyzed synthesis of N-fused heterocycles through regioselective 1,2-aminothiolation of 1,1-dibromoalkenes

The first aminothiolation of 1,1-dibromoalkene is described using an inexpensive copper/N,N-dimethylethylenediamine catalyst. The method provides a powerful means of using easily available 1,1-dihaloalkenes as precursors to fused heterocycles.

The Chemistry of Pyrimidinethiols. II. The Preparation and Reaction of Some 2-Arenecarbonylmethylthiopyrimidines

A number of 2-arenecarbonylmethylthiopyrimidin-4(1H)-ones has been synthesized.Those having H, Me or Pr as a 6-substituent undergo ready sulfur extrusion on heating in diphenyl ether to give 2-(arenecarbonylmethylene)-2,3-dihydropyrimidin-4(1H)-ones, but

Synthesis of Condensed Pyrimidine Derivatives from Heterocyclic Amines and 1,3-Dicarbonyl Compounds

Condensation of 2-amino-5-phenyl-1,3,4-oxadiazole (Ia) with ethyl acetoacetate in the presence of PPA gives 7-methyl-2-phenyl-5H-1,3,4-oxadiazolopyrimidin-5-one (IVa).However, a similar reaction of Ia using catalytic amounts of p-toluenesulphonic a