176495-21-9

Basic information

• Product Name: (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one
• Synonyms: (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one
• CAS NO: 176495-21-9
• Molecular Weight: 345.826
• Mol File: 176495-21-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one(176495-21-9)
• EPA Substance Registry System: (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one(176495-21-9)

Safety Data

• Hazardous Substances Data: 176495-21-9(Hazardous Substances Data)

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 176589-72-3 (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol 
• 20697-04-5 (R)-meta-chlorostyrene oxide 
• 58993-79-6 (R)-(-)-p-methoxyamphetamine 

Downstream Products

• 742676-98-8 (4-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-phenoxy)-methanesulfonic acid 
• 176495-23-1 (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one 

Relevant articles and documents

Carboxyl-promoted enhancement of selectivity for the β3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces β3 binding selectivity

Carboxyl and other negatively charged groups were found to be most effective at producing human β3 adrenergic receptor binding selectivity in 1 (BRL 37344) and related compounds. The sulfonic acid analog 7 (EMS-187413) is a novel and potent β3 adrenergic agonist that binds selectively, and thus has an in vitro profile that compares favorably with that of BRL 37344.