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176504-36-2

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176504-36-2 Usage

Description

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.

Uses

GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.

General Description

GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.

Biochem/physiol Actions

Inhibitor of protein kinase C; potent inhibitor of GSK-3.

Check Digit Verification of cas no

The CAS Registry Mumber 176504-36-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,6,5,0 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 176504-36:
(8*1)+(7*7)+(6*6)+(5*5)+(4*0)+(3*4)+(2*3)+(1*6)=142
142 % 10 = 2
So 176504-36-2 is a valid CAS Registry Number.

176504-36-2 Well-known Company Product Price

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  • Sigma

  • (B6292)  GF 109203X hydrochloride  ≥95%

  • 176504-36-2

  • B6292-250UG

  • 671.58CNY

  • Detail
  • Sigma

  • (B6292)  GF 109203X hydrochloride  ≥95%

  • 176504-36-2

  • B6292-1MG

  • 1,829.88CNY

  • Detail

176504-36-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione,hydrochloride

1.2 Other means of identification

Product number -
Other names Bisindolylmaleimide I,HCl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:176504-36-2 SDS

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