176516-01-1

Upstream product

• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 176515-90-5 4-Methyl-N-[2-(4-oxo-6-oxa-bicyclo[3.1.0]hex-1-yl)-ethyl]-benzenesulfonamide 
• 168908-04-1 4-Methyl-N-[2-(3-oxo-cyclopent-1-enyl)-ethyl]-benzenesulfonamide 

Relevant academic research and scientific papers

Conversion of δ-(sulfonyl)amino-α-epoxy ketones to bicyclic ketopyrroles via intramolecular conjugate-addition to azoene intermediates. Synthesis of the bicyclic ketopyrrole core of the 1-azafulvene roseophilin

Reaction of δ-(sulfonyl)amino-α-epoxy ketones with dimethylhydrazine results in cyclization to pyrrolidine-fused β-hydroxy dimethylhydrazones. Hydrolysis, mesylation, and elimination affords dihydropyrroles which can be converted to sulfonyl-protected ketopyrroles via oxidation with NIS; alternatively, treatment with DBU affords N-H bearing ketopyrroles. Copyright