176526-00-4

Basic information

• Product Name: 2-(4-Pyridyl)benzaldehyde
• Synonyms: 2-(4-PYRIDINYL)BENZALDEHYDE;2-(4-PYRIDYL)BENZALDEHYDE;2-PYRIDIN-4-YL-BENZALDEHYDE;AKOS BAR-1759;2-Pyridin-4-yl-benzaldehyd;2-PYRIDIN-4-YL-BENZALDEHYDE, 95+%
• CAS NO: 176526-00-4
• Molecular Formula: C₁₂H₉NO
• Molecular Weight: 183.21
• Product Categories: Heterocycles;Heterocyclic Compound;Benzaldehyde
• Mol File: 176526-00-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 342.797 °C at 760 mmHg
• Flash Point: 169.065 °C
• Appearance: /
• Density: 1.148 g/cm³
• Vapor Pressure: 7.35E-05mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Pyridyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Pyridyl)benzaldehyde(176526-00-4)
• EPA Substance Registry System: 2-(4-Pyridyl)benzaldehyde(176526-00-4)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 176526-00-4(Hazardous Substances Data)

Usage

General Description

2-(4-Pyridyl)benzaldehyde is a chemical compound with the molecular formula C12H9NO. It is a yellow to brown crystalline solid that is commonly used as a chemical intermediate and building block in the synthesis of various pharmaceuticals, agrochemicals, and dyes. 2-(4-Pyridyl)benzaldehyde possesses an aromatic benzene ring and a pyridine ring, and it is commonly used as a reagent in chemical reactions due to its ability to form complex organic molecules. It is also known for its characteristic odor and is commonly used in the fragrance industry. Additionally, it finds applications in the synthesis of chiral ligands and as a fluorescent probe for cellular imaging.

InChI:InChI=1/C12H9NO/c14-9-11-3-1-2-4-12(11)10-5-7-13-8-6-10/h1-9H

Upstream product

• 1692-15-5 4-pyridylboronic acid 
• 19524-06-2 4-bromopyridine hydrochloride 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1120-87-2 4-bromopyridin 
• 40138-16-7 2-formylbenzene boronic acid 

Downstream Products

• 1332500-54-5 4-methyl-N'-(2-(pyridin-4-yl)benzylidene)benzenesulfonohydrazide 
• 1033804-67-9 4-chloro-6-[2,2,2-trifluoro-1-(2-pyridin-4-yl-phenyl)ethoxy]pyrimidine 
• 1033804-65-7 (S)-2-amino-3-(4-{6-[2,2,2-trifluoro-1-(2-pyridin-4-yl-phenyl)-ethoxy]-pyrimidin-4-yl}-phenyl)-propionic acid 
• 83420-56-8 4-(2-ethynylphenyl)pyridine 
• 1375801-19-6 4-[2-(2-iodovinyl)phenyl]pyridine 
• 1022134-79-7 methyl 2-[1-hydroxy-1-{2-(pyridin-4-yl)phenyl}methyl]propenoate 
• 216443-81-1 4-[2-((E)-2-iodovinyl)phenyl]pyridine 
• 870063-38-0 4-(2-(azidomethyl)phenyl)pyridine 
• 1033804-66-8 2,2,2-trifluoro-1-(2-pyridin-4-yl-phenyl)ethanol 

Relevant articles and documents

A route to dihydro[2]benzooxepino[4,5-c]pyridines and dihydrothieno[d][2]benzooxepines via the 1.7-electrocyclisation of carbonyl ylides

The cyclisation of diene-conjugated carbonyl ylides of the general type 2, in which the α,β; γ,δ diene function is formed by a benzene ring and either a thiophene or pyridine ring provides a new route to some hetero-fused dihydrobenzooxepines. The oxirane

Intramolecular Acylation of Unactivated Pyridines or Arenes via Multiple C-H Functionalizations: Synthesis of All Four Azafluorenones and Fluorenones

An unprecedented intramolecular acylation of unactivated pyridines via multiple C(sp3/sp2)-H functionalizations of a methyl, hydroxymethyl, or aldehyde group has been developed providing a general access to all four azafluorenones. The application of this protocol is further demonstrated to the synthesis of azafluorenone related fused nitrogen heterocycles and fluorenones. In addition, design and synthesis of a novel fluorene based organic emitter for potential use in organic light emitting devices (OLEDs) is also reported.

Phosphine-Free Suzuki Cross-Coupling Reaction Using an Efficient and Reusable Pd Catalyst in an Aqueous Medium under Microwave Irradiation

We report here an improved, highly efficient, and general method for the ligand-free Suzuki cross-coupling reaction to the synthesis of biaryls, bipyridyls, thienylpyridine, and allylphenols. Microwave irradiation of (het)aryl halides and (hetaryl, allyl)arylboronic acid N-methyl-iminodiacetic acid (MIDA) ester, using polyurea microencapsulated palladium catalyst (Pd EnCat 30), gave the coupling adducts 1a-x in excellent yields in just 10-18 min.