176541-74-5Relevant academic research and scientific papers
IKCa-channel blockers. Part 2: Discovery of cyclohexadienes
Urbahns, Klaus,Goldmann, Siegfried,Krüger, Jochen,Horváth, Ervin,Schuhmacher, Joachim,Grosser, Rolf,Hinz, Volker,Mauler, Frank
, p. 401 - 404 (2007/10/03)
Novel cyclohexadienes have been identified as potent and specific IK Ca-channel blockers. In this communication we describe their synthesis as well as their chemical and biological properties. A selected derivative distributes well into brain and reduces the infarct volume, intracranial pressure as well as the water content in a rat subdural hematoma model of traumatic brain injury after iv administration. Novel cyclohexadienes have been identified as potent and specific IKCa-channel blockers. In this communication we describe their synthesis as well as their chemical and biological properties. A selected derivative is being enriched in rat brain and reduces the infarct volume, intracranial pressure as well as the water content in a rat subdural hematoma model of traumatic brain injury after iv administration.
