176641-33-1Relevant academic research and scientific papers
Facile Construction of Quinoline-2-carboxylate Esters through Aerobic Oxidation of Alkyl 4-Anilinocrotonates Induced by a Radical Cation Salt
Jia, Xiaodong,Li, Pengfei,Shao, Yu,Yuan, Yu,Hou, Wentao,Liu, Xiaofei,Zhang, Xuewen,Ji, Honghe
, p. 1719 - 1723 (2017)
A facile construction of quinoline-2-carboxylate esters through an aerobic oxidation of alkyl 4-anilinocrotonates is described. In the presence of dioxygen, sp3 C?H bonds in 4-anilinocrotonates can easily be oxidized by using a catalytic amount of a radical cation salt, providing a radical intermediate. After further oxidation and domino cyclization, the desired quinoline derivatives were afforded in high yields. This reaction provides a new way to construct the pharmaceutically relevant quinoline skeleton, avoiding harsh reaction conditions and tedious starting material synthesis.
