1767-28-8 Usage
Description
1-nitropyrene-6-ol, also known as 6-Nitro-1-pyrenol, is a urinary hydroxylated metabolite derived from the metabolism of polycyclic aromatic hydrocarbons (PAHs). It is characterized by its chemical structure, which includes a nitro group attached to a pyrene molecule with a hydroxyl group at the sixth position. 1-nitropyrene-6-ol plays a significant role in the assessment of human exposure to PAHs due to its presence in biological samples.
Uses
Used in Environmental and Occupational Health:
1-nitropyrene-6-ol is used as a biomarker for the assessment of exposure to polycyclic aromatic hydrocarbons (PAHs) in various settings. PAHs are a group of compounds that are found in the environment, primarily as a result of the incomplete combustion of organic materials such as coal, oil, and gas. They are known to have potential carcinogenic and mutagenic effects on humans and wildlife.
1-nitropyrene-6-ol is used as a biomarker to monitor the level of exposure to PAHs in individuals who are at risk due to their occupation or living conditions. This includes workers in industries such as coal mining, oil refining, and aluminum production, as well as people living in areas with high levels of air pollution.
Used in Research and Toxicology Studies:
1-nitropyrene-6-ol is also used as a biomarker in research and toxicology studies to investigate the effects of PAH exposure on human health. By measuring the levels of this metabolite in biological samples, researchers can gain insights into the mechanisms of PAH-induced toxicity and develop strategies for risk assessment and prevention.
Used in Public Health and Epidemiological Studies:
In public health and epidemiological studies, 1-nitropyrene-6-ol serves as a valuable biomarker for assessing the potential health risks associated with exposure to PAHs. By analyzing the levels of this metabolite in large populations, researchers can identify trends and correlations between PAH exposure and various health outcomes, such as cancer incidence and respiratory diseases.
Used in Regulatory and Compliance Monitoring:
1-nitropyrene-6-ol is utilized as a biomarker in regulatory and compliance monitoring to ensure that industries and organizations are adhering to environmental and occupational health standards. By measuring the levels of this metabolite in workers and the surrounding environment, authorities can enforce regulations and take corrective actions to minimize the risk of PAH exposure.
Check Digit Verification of cas no
The CAS Registry Mumber 1767-28-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,6 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1767-28:
(6*1)+(5*7)+(4*6)+(3*7)+(2*2)+(1*8)=98
98 % 10 = 8
So 1767-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H9NO3/c18-14-8-4-10-1-5-11-13(17(19)20)7-3-9-2-6-12(14)16(10)15(9)11/h1-8,18H
1767-28-8Relevant articles and documents
Photodegradation mechanisms of 1-nitropyrene, an environmental pollutant: The effect of organic solvents, water, oxygen, phenols, and polycyclic aromatics on the destruction and product yields
Garcia-Berrios, Zulma I.,Arce, Rafael
experimental part, p. 3662 - 3664 (2012/06/30)
This work describes studies of the photodegradation mechanism of 1-nitropyrene (1-NO2Py) in a chemical model system consisting of an organic solvent and known constituents of an aerosol particle. Photoproducts such as 1-hydroxypyrene (1-OHPy),
Determination of nitrated polynuclear aromatic hydrocarbons in particulate extracts by capillary column gas chromatography with nitrogen selective detection
Paputa Peck,Marano,Schuetzle,et al.
, p. 1946 - 1954 (2007/10/02)
The highly complex matrix of a diesel particulate extract was analyzed for nitrated polynuclear aromatic hydrocarbons (nitro-PAH) by use of fused-silica capillary column GC/thermionic nitrogen-phosphorus (GC/NPD) analysis of HPLC fractions. These samples were found to contain at least 100 nitro-PAH. Positive isomer identification for 17 nitro-PAH has been made utilizing the GC retention times of authentic standards and low- and high-resolution mass spectra as criteria. An additional 45 nitro-PAH were tentatively identified by using one or more of these techniques. Quantitative GC/MS analysis of 1-nitropyrene, 1,3-dinitropyrene, 1,6-di-nitropyrene, and 1,8-dinitropyrene was facilitated by the use of perdeuterated analogues of these compounds as internal standards. Detection limits by the GC/NPD method range between 0. 2 and 0. 5 ppm for the HPLC fractionated samples.
