176713-79-4Relevant academic research and scientific papers
Preparation method of large-steric-hindrance alkyl substituted phosphite diester
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Paragraph 0028-0031, (2020/04/06)
The invention discloses a preparation method of large-steric-hindrance alkyl substituted phosphite diester, and relates to a novel method for preparing the large-steric-hindrance alkyl substituted phosphite diester compound which is difficult to synthesiz
Highly effective alkaline earth catalysts for the sterically governed hydrophosphonylation of aldehydes and nonactivated ketones
Liu, Bo,Carpentier, Jean-Francois,Sarazin, Yann
, p. 13259 - 13264,6 (2012/12/12)
Down-to-earth catalysis: Heteroleptic and, more interestingly, homoleptic complexes of the large alkaline earth metals (calcium, strontium, and barium) constitute remarkably efficient catalysts for hydrophosphonylation reactions of aldehydes and nonactiva
Benzylphosphonic acid inhibitors of human prostatic acid phosphatase
Schwender,Beers,Malloy,Cinicola,Wustrow,Demarest,Jordan
, p. 311 - 314 (2007/10/03)
A series of α-substituted benzylphosphonic acids is described as inhibitors of human prostatic acid phosphatase, an enzyme has been used as a model to study aryl phosphatases. The most potent inhibitors in this series are 2-trifluoromethylbenzhydrylphosphonic acid (9 μM), and α-(2-phenylethyl)benzylphosphonic acid (14 μM). The structure-activity studies suggest that bulk tolerance beyond the phosphate binding area limits the steric or hydrophobic contribution to inhibitor potency achieved through α-carbon substitution.
