17672-23-0

Basic information

• Product Name: 2-Amino-3,6-dimethylphenol
• Synonyms: 2-Amino-3,6-dimethylphenol
• CAS NO: 17672-23-0
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 0
• Mol File: 17672-23-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Amino-3,6-dimethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3,6-dimethylphenol(17672-23-0)
• EPA Substance Registry System: 2-Amino-3,6-dimethylphenol(17672-23-0)

Safety Data

• Hazardous Substances Data: 17672-23-0(Hazardous Substances Data)

Usage

Structure

Aromatic amine with two methyl and one amino group attached to the phenol ring

Uses

Commonly used in hair dye formulations
Used in the synthesis of pharmaceuticals and dyes
Studied for potential antioxidant and anti-inflammatory properties

Hazards

Considered hazardous if ingested, inhaled, or in contact with skin
Exposure should be controlled and minimized

Upstream product

• 71608-10-1 2,5-dimethyl-6-nitrophenol 
• 95-78-3 2,5-Dimethylaniline 
• 112656-97-0 sulfuric acid mono-(2-amino-3,6-dimethyl-phenyl ester) 

Downstream Products

• 273-53-0 benzoxazole 
• 139393-93-4 2-(chloromethyl)-4,7-dimethylbenzoxazole 
• 115020-40-1 2-benzoylamino-3-benzoyloxy-1,4-dimethyl-benzene 

Relevant articles and documents

Antitumor agents. 5. Synthesis, structure - activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-benzopyridophenoxazin-5-ones with potent antiproliferative activity

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1-6), tetrahydro-5H-benzopyrido[2,3-j]phenoxazin-5-ones (7-9), and 5H-benzopyrido[3,2-a]phenoxazin-5-ones (10-12) were synthesized and evaluated against representative human neoplastic cell lines. Dimethyl derivatives 1-6 were more active against carcinoma than leukemia cell lines. The tetrahydrobenzo derivatives 7-9 were scarcely active, whereas the corresponding benzo derivatives 10-12 showed notable cytotoxicity against a majority of the tested cell lines. Molecular modeling studies indicated that the high potency of 10 and 11, the most cytotoxic compounds of the whole series, could be due to the position of the condensed benzene ring, which favors π-π stacking interactions with purine and pyrimidine bases in the DNA active site. Biological studies suggested that 10-12 have no effect on human topoisomerases I and II and that they induce arrest at the G2/M phase.

Alkyl-substituted benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same

A novel rifamycin derivative having the formula (I): STR1 wherein X1 is an alkyl group with 1 to 6 carbon atoms or a cycloalkyl group with 3 to 8 carbon atoms; X2 is a hydrogen atom or an alkyl group with 1 to 4 carbon atoms; R1 is hydrogen atom or acetyl group; A is a group represented by the formula: STR2 wherein R2 is an alkyl group with 1 to 4 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms and R3 is an alkyl group with 1 to 6 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms, or a group represented by the formula STR3 wherein STR4 is a 3 to 9 membered cyclic amino group with 2 to 8 carbon atoms, R4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or salts thereof, a process for preparing the same and antibacterial agents containing the same as an effective ingredient. The rifamycin derivative of the present invention having the formula (I) shows a strong antibacterial activity against the Gram-positive bacteria and the acid-fast bacteria.