17672-28-5

Usage

Uses

Used in Chemical Synthesis:
(4-Phenoxy-Phenyl)-Hydrazine is used as a reagent in chemical synthesis for its unique properties and reactivity, allowing for the creation of various complex molecules and compounds.
Used in Drug Development:
(4-Phenoxy-Phenyl)-Hydrazine is used as a building block in drug development, contributing to the formation of new pharmaceutical compounds with potential therapeutic applications.
Used in Research and Development:
(4-Phenoxy-Phenyl)-Hydrazine is used as a research compound in various scientific studies, helping to understand its properties and potential applications in different fields, including materials science and pharmaceuticals.
Used in Industrial Applications:
(4-Phenoxy-Phenyl)-Hydrazine is used as a chemical intermediate in the production of various industrial products, such as dyes, pigments, and specialty chemicals, due to its unique chemical structure and reactivity.

InChI:InChI=1/C12H12N2O/c13-14-10-6-8-12(9-7-10)15-11-4-2-1-3-5-11/h1-9,14H,13H2

Upstream product

• 6099-72-5 4-Phenoxy-benzoldiazonium-chlorid 
• 139-59-3 4-phenoxyanilin 

Downstream Products

• 6119-09-1 1-(4-phenoxy-phenyl)-pyrazolidin-3-one 
• 78304-52-6 5-phenoxy-2-carboxyindole 

Relevant academic research and scientific papers

Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors

Inhibition of xanthine oxidase (XO) has obviously been a central concept for controlling hyperuricemia, which causes serious and painful inflammatory arthritis disease such as gout. We discovered a series of novel 2-(indol-2-yl)thiazole derivatives as XO inhibitors at the level of nanomolar activity. Structure-guided design using molecular modeling program (Accelrys Software program) provided an excellent basis for optimization of 2-(indol-2-yl)thiazole compounds. Structure-activity relationship indicated that hydrophobic alkoxy group (isopropoxy, cyclopentoxy) at 5-position and hydrogen binding acceptor (NO2, CN) at 7-position of indole ring appear as critical functional groups. Among the compounds, 2-(7-nitro-5-isopropoxy-indol-2-yl)-4-methylthiazole-5-carboxylic acid (9m) exhibits the most potent XO inhibitory activity (IC50value: 5.1 nM) and the excellent uric acid lowering activity in potassium oxonate induced hyperuricemic rat model.

SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK AND THEIR PREPARATION AND USE IN THE TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASE

Compounds of Formula I, as shown below and defined herein: and pharmaceutically acceptable salts, syntheses, intermediates, formulations, and methods of treating diseases including cancer, inflammation, and autoimmune disease mediated at least in part by Bruton's Tyrosine Kinase (BTK).

Mnk1 or Mnk2 inhibitors

The present invention relates to novel pharmaceutical compositions comprising pyrazolopyrimidine compounds. Moreover, the present invention relates to the use of the pyrazolopyrimidine compounds of the invention for the production of pharmaceutical compos

Process for producing 3-anilino-5-pyrazolones

A process for producing a 3-anilino-5-pyrazolone which comprises reacting a β-anilino-β-alkoxy-acrylate with a hydrazine in the presence of a compound having a pKa of about 8 up to about 14.