17672-28-5

Basic information

• Product Name: (4-PHENOXY-PHENYL)-HYDRAZINE
• Synonyms: (4-PHENOXY-PHENYL)-HYDRAZINE
• CAS NO: 17672-28-5
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Mol File: 17672-28-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 56-57 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 352.9 °C at 760 mmHg
• Flash Point: 167.2 °C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 3.71E-05mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: 2-8°C
• PKA: 5.32±0.20(Predicted)
• CAS DataBase Reference: (4-PHENOXY-PHENYL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-PHENOXY-PHENYL)-HYDRAZINE(17672-28-5)
• EPA Substance Registry System: (4-PHENOXY-PHENYL)-HYDRAZINE(17672-28-5)

Safety Data

• Hazardous Substances Data: 17672-28-5(Hazardous Substances Data)

Usage

General Description

"(4-Phenoxy-Phenyl)-Hydrazine" is a chemical compound that belongs to the class of organic compounds known as diphenyl ethers. Diphenyl ethers are aromatic compounds containing two phenyl groups connected through an ether group. "(4-Phenoxy-Phenyl)-Hydrazine" incorporates a hydrazine functional group that involves an organic alkyl chain, composed of hydrogen and nitrogen atoms. Its specific behaviour and characteristics, such as its reactivity, solubility and boiling or melting points, depend on its specific properties and molecular structure. It is often used in chemical synthesis and drug development due to its properties. However, like all hydrazines, it should be handled with caution because of its potential toxicity and explosiveness.

InChI:InChI=1/C12H12N2O/c13-14-10-6-8-12(9-7-10)15-11-4-2-1-3-5-11/h1-9,14H,13H2

Upstream product

• 139-59-3 4-phenoxyanilin 
• 6099-72-5 4-Phenoxy-benzoldiazonium-chlorid 

Downstream Products

• 6119-09-1 1-(4-phenoxy-phenyl)-pyrazolidin-3-one 
• 78304-52-6 5-phenoxy-2-carboxyindole 

Relevant articles and documents

Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors

Inhibition of xanthine oxidase (XO) has obviously been a central concept for controlling hyperuricemia, which causes serious and painful inflammatory arthritis disease such as gout. We discovered a series of novel 2-(indol-2-yl)thiazole derivatives as XO inhibitors at the level of nanomolar activity. Structure-guided design using molecular modeling program (Accelrys Software program) provided an excellent basis for optimization of 2-(indol-2-yl)thiazole compounds. Structure-activity relationship indicated that hydrophobic alkoxy group (isopropoxy, cyclopentoxy) at 5-position and hydrogen binding acceptor (NO2, CN) at 7-position of indole ring appear as critical functional groups. Among the compounds, 2-(7-nitro-5-isopropoxy-indol-2-yl)-4-methylthiazole-5-carboxylic acid (9m) exhibits the most potent XO inhibitory activity (IC50value: 5.1 nM) and the excellent uric acid lowering activity in potassium oxonate induced hyperuricemic rat model.

Mnk1 or Mnk2 inhibitors

The present invention relates to novel pharmaceutical compositions comprising pyrazolopyrimidine compounds. Moreover, the present invention relates to the use of the pyrazolopyrimidine compounds of the invention for the production of pharmaceutical compos