17680-84-1Relevant academic research and scientific papers
Preparation method of homoplantaginin
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, (2020/08/18)
The invention relates to the field of chemical synthesis, in particular to a novel preparation method of homoplantaginin. The method employs scutellarin as a raw material and can be used for efficiently semi-synthesizing the homoplantaginin from the scutellarin through three steps of reactions of carboxyl esterification, selective methylation and ester group reduction. The method is short in reaction step, high in reaction yield, mild in reaction condition and easy to operate, provides a necessary material basis for further research on the biological activity of the homoplantaginin, and has arelatively good application and development prospect.
Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin
Ding, Ning,Li, Yingxia,Wang, Yujie,Xiao, Qiang,Xie, Mingxian,Yan, Shiqiang
, (2020/01/22)
Natural flavonoids and flavonoid glycosides exist in many plants and have been demonstrated to possess various clinically relevant properties, isolating large amounts of these compounds that have striking structural similarity from plant sources needs tedious isolation techniques. These processes limited their availability in structural diversity for structure?activity relationship (SAR) studies, and restrict large quantities for, as an example, their mechanistic evaluation of the in vivo activities. In this work, we developed a semi-synthetic strategy from scutellarin for the synthesis of a series of natural flavonoids and flavonoid glycosides. By taking this strategy, eight bioactive flavonoids with striking structural similarities were synthesized efficiently and practically. The sufficient amounts obtained products will greatly facilitate the SAR studies and mechanistic evaluation of the in vivo activities.
