17683-95-3Relevant academic research and scientific papers
A versatile and highly efficient method for 1-chlorination of terminal and trialkylsilyl-protected alkynes
Gulia, Nurbey,Pigulski, Bartlomiej,Charewicz, Marta,Szafert, Slawomir
supporting information, p. 2746 - 2749 (2014/03/21)
A highly efficient one-pot procedure for the preparation of 1-chloroalkynes and 1-chlorobutadiynes from terminal and trialkylsilyl-protected precursors is reported. This convenient reaction, proceeding under mild conditions, utilizes N-chlorosuccinimide as the chlorinating agent and tolerates a range of functional groups. A general chlorination of alkynes: A highly efficient one-pot procedure for the preparation of 1-chloroalkynes and 1-chlorobutadiynes from terminal and trialkylsilyl-protected precursors is reported (see figure; TMS=trimethylsilyl, TES=triethylsilyl, TBDMS=tert-butyldimethylsilyl, TIPS=triisopropylsilyl). This convenient reaction, proceeding under mild conditions, utilizes N-chlorosuccinimide as the chlorinating agent and tolerates a range of functional groups.
