176858-05-2

Basic information

• Product Name: Sulfamide, bis[(4-methylphenyl)methylene]-
• CAS NO: 176858-05-2
• Molecular Formula: C16H16N2O2S
• Molecular Weight: 300.381
• Mol File: 176858-05-2.mol

Chemical Properties

• CAS DataBase Reference: Sulfamide, bis[(4-methylphenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamide, bis[(4-methylphenyl)methylene]-(176858-05-2)
• EPA Substance Registry System: Sulfamide, bis[(4-methylphenyl)methylene]-(176858-05-2)

Safety Data

• Hazardous Substances Data: 176858-05-2(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 1309582-60-2 N,N'-sulfonyl bis-[(S)-(4-methylphenyl)(phenyl)methylamine] 
• 124842-96-2 meso-1,2-bis(4-methylphenyl)ethylenediamine 
• 3775-19-7 3,4-di-p-tolyl-[1,2,5]thiadiazolidine 1,1-dioxide 

Relevant articles and documents

Bis-sulfamyl imines: Potent substrates for asymmetric additions of arylboroxines under rhodium catalysis

Bis-sulfamyl imines are shown to be potentially ideal substrates for rhodium-catalysed asymmetric additions of arylboron nucleophiles as they show: (i) near perfect enantioselectivities (11 examples, 98-99+% ee), (ii) good to excellent diastereoselectivities (10-32:1 rac:meso), and (iii) high functional group tolerance in removal of the low molecular weight protecting group via mild heating in aqueous pyridine.

Intramolecular imine cross-coupling in dibenzylidine sulfamides: Synthesis of unsymmetrical 1,2-diaryl ethanediamines

Intramolecular reductive cross-coupling of unsymmetrical dibenzylidene sulfamides generates the corresponding cyclic sulfamides in good yield. These intermediates are readily converted to the free, unsymmetrical 1,2-diaryl ethanediamines.