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176860-57-4

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176860-57-4 Usage

General Description

2-(3,4-dichloro-phenyl)-N-hydroxy-acetamidine, also known as rufinamide, is an anticonvulsant medication used to treat seizures associated with Lennox-Gastaut syndrome in children and adults. It works by stabilizing nerve cells in the brain to prevent abnormal electrical activity and reduce the frequency of seizures. This chemical is a derivative of acetamidine and has a hydroxy group attached to the nitrogen atom. It is a white to off-white powder that is freely soluble in water and organic solvents and is typically administered in the form of tablets or oral suspension. Rufinamide is a valuable option for managing difficult-to-control seizures and has been shown to be effective in reducing seizure frequency and improving overall quality of life for patients with Lennox-Gastaut syndrome.

Check Digit Verification of cas no

The CAS Registry Mumber 176860-57-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,6,8,6 and 0 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 176860-57:
(8*1)+(7*7)+(6*6)+(5*8)+(4*6)+(3*0)+(2*5)+(1*7)=174
174 % 10 = 4
So 176860-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H8Cl2N2O/c9-6-2-1-5(3-7(6)10)4-8(11)12-13/h1-3,13H,4H2,(H2,11,12)

176860-57-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(3,4-DICHLORO-PHENYL)-N-HYDROXY-ACETAMIDINE

1.2 Other means of identification

Product number -
Other names 2-(3,4-dichlorophenyl)-N-hydroxyethanimidamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:176860-57-4 SDS

176860-57-4Relevant articles and documents

Nitrobenzofurazan derivatives of N′-hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1

Paul, Saurav,Roy, Ashalata,Deka, Suman Jyoti,Panda, Subhankar,Trivedi, Vishal,Manna, Debasis

, p. 364 - 375 (2016/06/13)

Tryptophan metabolism through the kynurenine pathway is considered as a crucial mechanism in immune tolerance. Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in tryptophan catabolism in the immune system and it is also considered as an important therapeutic target for the treatment of cancer and other diseases that are linked with kynurenine pathway. In this study, a series of nitrobenzofurazan derivatives of N′-hydroxybenzimidamides (1) and N′-hydroxy-2-phenylacetimidamides (2) were synthesized and their inhibitory activities against human IDO1 enzyme were tested using in-vitro and cellular enzyme activity assay. The optimization leads to the identification of potent compounds, 1d, 2i and 2k (IC50 = 39-80 nM), which are either competitive or uncompetitive inhibitors of IDO1 enzyme. These compounds also showed IDO1 inhibition potencies in the nanomolar range (IC50 = 50-71 nM) in MDA-MB-231 cells with no/negligible amount of cytotoxicity. The stronger selectivity of the potent compounds for IDO1 enzyme over tryptophan 2,3-dioxygenase (TDO) enzyme (312-1593-fold) also makes them very attractive for further immunotherapeutic applications.

RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: Design, biochemical activity, and structural information

Kirschberg, Thorsten A.,Balakrishnan, Mini,Squires, Neil H.,Barnes, Tiffany,Brendza, Katherine M.,Chen, Xiaowu,Eisenberg, Eugene J.,Jin, Weili,Kutty, Nilima,Leavitt, Stephanie,Liclican, Albert,Liu, Qi,Liu, Xiaohong,Mak, John,Perry, Jason K.,Wang, Michael,Watkins, William J.,Lansdon, Eric B.

supporting information; experimental part, p. 5781 - 5784 (2010/03/24)

Pyrimidinol carboxylic acids were designed as inhibitors of HIV-1 RNase H function. These molecules can coordinate to two divalent metal ions in the RNase H active site. Inhibition of enzymatic activity was measured in a biochemical assay, but no antivira

Substituted phenyl-amidines

-

, (2008/06/13)

The present invention provides compounds of the formula: STR1 in which A is CH2, CHOH, CH2 O, CH2 S, CH2 NH, OCH2, SCH2, NH, NHCH2, NHCOCH2 or CH2 NHCH2, X1 is H, halogen, C1 -C4 -alkyl or C1 -C4 -alkoxy, X2 is halogen, C1 -C4 -alkyl or C1 -C4 -alkoxy, Z is 2-pyrimidinyl or C(=NR1)NHR2 (where R1 is H and R2 is H, OH or CH2 CO2 Et, or R1 and R2 together form CH2 CH2, CH2 CH2 CH2 or N=N), and their addition salts. The compounds of formula I and their salts are useful in therapy as hypotensive agents.

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