176907-01-0Relevant articles and documents
Synthesis and Structure of (Carboxymethyl)-Functionalized Cyclobuta-Fused Uracil Dimers
Carell, Thomas,Epple, Robert,Gramlich, Volker
, p. 2191 - 2203 (2007/10/03)
Herein, we report a convenient method for the preparation of four benzyl-ester-protected, (carboxymethyl)-functionalized cyclobuta-fused uracil dimers 1-4, including the desired cis-cisoid-cis,syn-configured isomer 1, a compound which is suitable for the preparation of catalytic antibodies, synthetic receptors, and model compounds, required for the investigation of the DNA-lesion, recognition step and DNA-repair mechanisms. A comprehensive structure determination of each isomer by 1H-NMR, and in the case of the cis-cisoid-cis,syn-and the cis-transoid-cis-cis,syn-dimers by X-ray crystal-structure analysis, is also provided.
Zur DNA-Reparatur durch das Enzym DNA-Photolyase: Synthese von Flavin enthaltenden Modellverbindungen
Carell, Thomas,Epple, Robert,Gramlich, Volker
, p. 676 - 679 (2007/10/03)
Keywords: DNA-Reparatur; Elektronentransfer; Flavine; Nucleobasen