17692-38-5

Basic information

• Product Name: Fluprofen
• Synonyms: 3'-Fluoro-α-methylbiphenyl-4-acetic acid;BTS-17345;RD-17345
• CAS NO: 17692-38-5
• Molecular Formula: C15H13FO2
• Molecular Weight: 244.264
• Mol File: 17692-38-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 389.5 °C at 760 mmHg
• Flash Point: 189.3 °C
• Appearance: /
• Density: 1.199 g/cm³
• Vapor Pressure: 9.18E-07mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: Fluprofen(CAS DataBase Reference)
• NIST Chemistry Reference: Fluprofen(17692-38-5)
• EPA Substance Registry System: Fluprofen(17692-38-5)

Safety Data

• Hazardous Substances Data: 17692-38-5(Hazardous Substances Data)

Usage

General Description

Fluprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation in the body. It is commonly used to relieve pain and inflammation associated with conditions such as arthritis, menstrual cramps, and muscle strains. Fluprofen is available in both oral and topical forms, with the oral form typically taken two to three times daily with food. Common side effects of fluprofen include stomach pain, heartburn, and nausea, and more serious side effects such as gastrointestinal bleeding and kidney problems may also occur with prolonged use. It is important to use fluprofen only as directed by a healthcare professional and to be aware of its potential risks and interactions with other medications.

InChI:InChI=1/C15H13FO2/c1-10(15(17)18)11-5-7-12(8-6-11)13-3-2-4-14(16)9-13/h2-10H,1H3,(H,17,18)

Relevant articles and documents

High molecular weight prodrug derivatives of antiinflammatory drugs

Compounds of the formula 1, PS - O - A - (CH2)n- B - D (1), wherein PS-O represents an alkoxide residue of any of the free hydroxy groups of a polysaccharide (PS-OH) compound with molecular weight (Mw) of from 40,000 to 5,000,000 selected from dextran, carboxymethyl dextran, diethylaminoethyl dextran, starch, hydroxyet-hyl starch, alginates, glycogen, pullullan, agarose, cellulose, chitosan, chitin and carrageenan,A is a carbonyl group or absent,n is zero or a positive integer from 1 to 14,B is oxygen, a carbonyl group, NR wherein R is hydrogen or lower alkyl, or B is absent, and, D is (i) a group of the formula:, R1 - CO - (11), wherein R1-CO- represents the acyl residue of a carboxylic acid drug (R1-COOH) used in the treatment of inflammatory disorders; or (ii) a group of the formula:, R2 - O - (12), wherein R2-O- refers to the C-21 alkoxide residue of a known antiinflammatory steroid (R2-OH) or an alkoxide residue of any other drug or medicament containing a hydroxy functional group used in the treatment of inflammatory disorders; with the proviso that when A is absent, n is 0, and B is absent, then R1-CO- is different from the acyl residue of acetylsalicylic acid;, and non-toxic pharmaceutically acceptable acid addition salts thereof;, and non-toxic pharmaceutically acceptable cation salts thereof. Such compounds are biolabile prodrugs providing controlled release and prolonged duration of action of the parent active antiinflamma-tory agents locally at the administration site after intra-articular, intra-muscular, subcutaneous or extra-dural application while at the same time being highly stable in aqueous solution in the pH range 3--5. After oral administration of such prodrugs the parent drug is liberated selectively in the terminal ileum and the colon over an extended period of time.