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17695-48-6

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17695-48-6 Usage

Description

4-METHYLUMBELLIFERYL PALMITATE is a white to off-white crystalline powder that belongs to the class of fatty acyl esters of 4-methylumbelliferone. It is primarily used as a fluorogenic substrate to monitor the hydrolytic activity of carboxylesterases, such as acid and alkaline lipases.

Uses

Used in Research and Diagnostics:
4-METHYLUMBELLIFERYL PALMITATE is used as a fluorogenic substrate for the continuous monitoring of carboxylesterase activity. This application is crucial in research and diagnostics, as it helps in the study and detection of various enzymatic processes and their role in different biological systems.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-METHYLUMBELLIFERYL PALMITATE is used as a tool to evaluate the effectiveness of drugs targeting carboxylesterases. This helps in the development of new therapeutic agents and the optimization of existing ones, ultimately contributing to the advancement of medical treatments.
Used in Analytical Chemistry:
4-METHYLUMBELLIFERYL PALMITATE is employed as a reagent in analytical chemistry for the detection and quantification of carboxylesterase activity. This is particularly useful in the development of assays and the study of enzyme kinetics, providing valuable insights into the mechanisms of these enzymes and their interactions with substrates and inhibitors.

Check Digit Verification of cas no

The CAS Registry Mumber 17695-48-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,6,9 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17695-48:
(7*1)+(6*7)+(5*6)+(4*9)+(3*5)+(2*4)+(1*8)=146
146 % 10 = 6
So 17695-48-6 is a valid CAS Registry Number.
InChI:InChI=1/C26H38O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-25(27)29-22-17-18-23-21(2)19-26(28)30-24(23)20-22/h17-20H,3-16H2,1-2H3

17695-48-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Palmitic acid 4-methylumbelliferyl ester

1.2 Other means of identification

Product number -
Other names (4-methyl-2-oxochromen-7-yl) hexadecanoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17695-48-6 SDS

17695-48-6Relevant articles and documents

A new class of pure estrogen alpha receptor antagonists; design, synthesis and in-vitro screening

Jameera Begam, Akbar John,Basheer, Katike Ahamed,Jubie, Selvaraj,Jupudi, Srikanth,Azam, Mohammed Afzal,Dhanabal, Palanisamy

, p. 66 - 81 (2019/01/04)

Background: In view of the estrogenic receptor inhibitory properties of coumarin nucleus, long chain nature of fatty acid and anti-breast cancer activity of fatty acids, it was proposed to attach long chain fatty acids at 3rd,4th and 7th position of coumarin nucleus and evaluate for their anti-breast cancer activity through suitable in-vitro methods. Methods: The present study focuses a library of fatty acid coumarin conjugates as ligands to the ligand-binding domain of the human estrogen receptor α (PDB ID 2IOG) and their binding affinities using GLIDE module of Schrodinger after ascertaining their drug-likeness with QIKPROP. The compounds LNAC 8, SAC 1 and OAC 5 are the best hits based on their docking scores as well as the Prime MM-GBSA free energy of binding. Based on the in-silico results and synthetic feasibility the compounds SAC 1 PAC 1 and OAC 1 are synthesized, characterized and investigated for their time interval growth inhibitory effect on MCF-7 which is an ER positive breast cancer cell lines. Results: SAC 1, showed better in vitro growth inhibitory effect in sub micromolar range as compared to Tamoxifen, a standard estrogen receptor modulator. Conclusion: Conclusively, in silico molecular docking studies have been very useful in predicting the pharmacokinetic profiles and the binding affinities of new hits before a detailed preclinical and clinical evaluation.

A high-throughput, low-volume enzyme assay on solid support

Babiak, Peter,Reymond, Jean-Louis

, p. 373 - 377 (2007/10/03)

A high-throughput enzyme assay is described that uses 1 μL or less of enzyme solution for each test Enzyme solutions are deposited by robotic handling in a throughput of over 1000 tests/h on the surface of silica gel plates that have been preimpregnated with fluorogenic substrates. The reaction is quantitated by fluorescence. The method is compatible with water-insoluble substrates (lipases), water-soluble substrates (glycosidases), whole-protein substrates (proteases), and enzyme inhibition measurements. Hydrolytically labile umbelliferyl esters can be used to assay lipases in this format without background hydrolysis. High throughput and reproducibility were tested by fingerprint analysis of lipases and esterases against 37 different fluorogenic ester substrates. A set of eight fluorogenic unbelliferyl esters was selected for optimal activity screening of lipases and esterases on silica gel plates.

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