17696-93-4Relevant academic research and scientific papers
Tandem synthesis of highly functionalized 1,2,3-benzotriazines from isocyanides, aniline and dialkyl azadicarboxylate via Cu-catalyzed intramolecular C[sbnd]H activation reactions
Nematpour, Manijeh,Sedaghat, Anna,Dastjerdi, Hossein Fasihi,Tabatabai, Sayyed Abbas
supporting information, (2020/02/18)
A class of substituted 1,2,3-benzotriazines are obtained in tandem mode reaction by means of Cu-catalyzed intramolecular C[sbnd]H activation of aniline, isocyanides and dialkyl azadicarboxylate in acetonitrile at room temperature in good yields. The speed
Hexafluoro-2-propanol Promotes para-Selective C–H Amination of Free Anilines with Azodicarboxylates
Tang, Ren-Jin,Milcent, Thierry,Crousse, Benoit
supporting information, p. 4753 - 4757 (2017/09/07)
An effective, mild, and clean method for the C–H amination of free anilines with azodicarboxylates in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) without the need for any additional catalysts or reagents was developed. The reaction was found to be highly regioselective and provided a series of p-aminophenylhydrazine derivatives in excellent yields. Moreover, compatibility with a free amino group makes this protocol an attractive strategy in synthetic chemistry.
