17696-94-5

Usage

Uses

Used in Pharmaceutical Research:
Ethyl 3-(N-phenylcarbamoyl)carbazate is used as a reagent in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Synthesis:
In the agrochemical industry, ethyl 3-(N-phenylcarbamoyl)carbazate is employed as a reagent for the synthesis of agrochemicals, aiding in the creation of products for agricultural applications.
Used in Carbazole Derivative Preparation:
Ethyl 3-(N-phenylcarbamoyl)carbazate is used in the preparation of carbazole derivatives, which have potential applications as antioxidants, anticonvulsants, and anti-tumor agents, indicating its importance in the development of compounds with medicinal properties.
Used in Chelating Agent Research:
ethyl 3-(N-phenylcarbamoyl)carbazate has been studied for its potential as a chelating agent, suggesting its use in applications where metal ion binding and complexation are required, such as in environmental remediation or chemical analysis.
Used in Antimicrobial Applications:
Ethyl 3-(N-phenylcarbamoyl)carbazate has also been investigated for its antimicrobial properties, indicating its potential use in the development of antimicrobial agents to combat microbial infections.

InChI:InChI=1/C10H13N3O3/c1-2-16-10(15)13-12-9(14)11-8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H,13,15)(H2,11,12,14)

Upstream product

• 6320-72-5 4-nitrophenyl-N-phenyl carbamate 
• 4114-31-2 ethylhydrazine carboxylate 
• 85210-15-7 1-ethyl 2-phenyl hydrazine-1,2-dicarboxylate 
• 62-53-3 aniline 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 1234426-74-4 3-dimethylamino-6-phenyl-1,1,5,7-tetraoxo-1λ6-[1,2,4]triazolo[1,2-b][1,2,3,5]thiatriazole 
• 1234426-76-6 3-diethylamino-6-phenyl-1,1,5,7-tetraoxo-1λ6-[1,2,4]triazolo[1,2-b][1,2,3,5]thiatriazole 
• 1234426-78-8 3-pyrrolidin-1-yl-6-phenyl-1,1,5,7-tetraoxo-1λ6-[1,2,4]triazolo[1,2-b][1,2,3,5]thiatriazole 
• 4233-33-4 4-Phenyl-1,2,4-triazolidine-3,5-dione 
• 131290-11-4 C₁₀H₁₁N₃O₃ 
• 15988-11-1 4-Phenylurazole 
• 53922-43-3 ethyl phenylaminocarbonyldiazenecarboxylate 

Relevant academic research and scientific papers

METHOD FOR PRODUCING SEMICARBAZIDE COMPOUND

Provided is a method for producing a high-purity, high-quality semicarbazide compound at a high yield by a simple method. The semicarbazide compound is recrystallized by a solvent containing a halogenated hydrocarbon. Dichloromethane is preferred as the halogenated hydrocarbon.

IMPROVED SYNTHESIS OF 4-ARYL-1,2,4-TRIAZOLIDINE-3,5-DIONES AND 4-ARYL-1,2,4-TRIAZOLINE-3,5-DIONES

The present invention relates to a method of preparing 4-aryl-1,2,4- triazolidine-3,5-dione of the formula (I) and 4-aryl-1,2,4-triazole-3,5-dione of the formula (VII). This method is particularly suitable as the synthesis of 4-aryl-1,2,4-triazolidine-3,5-dione of the formula (I) is made from the respective arylisocyanate of the formula (II) with a hydrazine carboxylate as a one pot reaction in an alcohol.

Alternative synthetic routes to N-methyl-1,2,4-triazoline-3,5-dione (MeTAD) and other triazolinedione derivatives

N-Methyl-1,2,4-triazoline-3,5-dione (MeTAD) is a powerful electrophile and a versatile synthetic reagent. In this Letter we describe two methods for the synthesis of N-methylurazole, the direct precursor to MeTAD, on gram scales and in good yields. Both methods provide pure urazole while avoiding the necessity of large scale purification via column chromatography or recrystallization. One of the methods proved to be amenable for the synthesis of derivatives other than N-methyl.

N,N-Dialkyl-N′-chlorosulfonyl chloroformamidines in heterocyclic synthesis. part IX.* novel triazolo-fused thiatriazoles and pyrazolo-fused oxathiazines

N,N-dialkyl-N′-chlorosulfonyl chloroformamidines 1 reacted with 4-substituted urazoles 2 to give [1,2,4]triazolo[1,2-b] [1,2,3,5]thiatriazoles 3 in a selective 1,2-NN dinucleophilic mode of reaction.The reaction of 1 with N1-substituted pyrazol-5-ones 4 afforded pyrazolo[4,3-e][1,4,3] oxathiazines 5 via selective 1,3-CCO dinucleophilic substitution. Compounds 3 and 5 were the sole products isolated from the respective reactions and both represent new ring systems. CSIRO 2010.

Novel and efficient synthesis of 4-substituted-1,2,4-triazolidine-3,5- diones from anilines

A simple and efficient three-step synthetic procedure for the preparation of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles), starting from anilines, has been developed. In this method, aniline derivatives were reacted with 4-nitrophenyl chloroformate to provide corresponding carbamate derivatives. In the second step, semicarbazide derivatives were prepared from these carbamates by reaction with ethyl carbazate. The cyclization reaction of corresponding semicarbazides furnished 1,2,4-triazolidindiones in high yields. Copyright Taylor & Francis Group, LLC.

Diazenedicarboxamides as inhibitors of d-alanine-d-alanine ligase (Ddl)

d-Alanine-d-alanine ligase (Ddl) catalyzes the biosynthesis of an essential bacterial peptidoglycan precursor d-alanyl-d-alanine and it represents an important target for development of new antibacterial drugs. A series of semicarbazides, aminocarbonyldiazenecarboxylates, diazenedicarboxamides, and hydrazinedicarboxamides was synthesized and screened for inhibition of DdlB from Escherichia coli. Compounds with good inhibitory activity were identified, enabling us to deduce initial structure-activity relationships. Thirteen diazenedicarboxamides were better inhibitors than d-cycloserine and some of them also possess antibacterial activity, which makes them a promising starting point for further development.

Microwave Assisted Synthesis of 4-Substituted 1-Ethoxycarbonyl Semicarbazides from Ethyl Carbazate and Isocyanates

A rapid and simple method for the preparation of 4-substituted 1-ethoxycarbonyl semi[0-9] carbazide is reported. The reaction is carried out under microwave irradiation by the reaction of five different isocyanates with ethyl carbazate.

Solid-state synthesis of 1-ethoxycarbonyl-4-substituted-semicarbazides

A rapid and simple method for the preparation of 1-ethoxycarbonyl-4- substituted-semicarbazides has been developed. As examples the reaction of six different isocyanates with ethyl carbazate under solvent-free conditions are reported.