176963-08-9

Upstream product

• 176963-05-6 1-ethyl-7-methoxy-3-methyl-2-phenylindole 
• 176963-03-4 7-methoxy-3-methyl-2-phenylindole 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 90-04-0 2-methoxy-phenylamine 
• 107-30-2 chloromethyl methyl ether 
• 1026954-75-5 1-Ethyl-3-methyl-2-phenyl-1H-indol-7-ol 

Downstream Products

• 1026010-13-8 ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate 
• 176963-17-0 1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-carbaldehyde 
• 176963-14-7 1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole 
• 176963-11-4 1-ethyl-7-(methoxymethoxy)-3-methyl-2-phenylindole-6-carbaldehyde 

Relevant academic research and scientific papers

Hydroxyindole derivatives as inhibitors of IL-1 generation. II. Synthesis and pharmacological activities of (E)3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives

A series of (E)-3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives was prepared and the inhibitory activities of its members on IL-1 generation were evaluated in an in vitro system using exudate cells from the rat carboxy-methyl cellulose (CMC) induced air-pouch model. All the compounds in this new series were found to be inhibitors of IL-1 generation. In particular, the methoxy-substituted 2-phenyl compounds 28d-f were the most potent inhibitors of IL-1 generation (eg, 28d: IC50 = 0.8 μ,M). The compounds in this series also inhibited IL-1α and IL-1β generations in an in vitro system using human monocytes stimulated with LPS (eg, 28b: IC50 = 1.4 μM (IL-1α) and 0.9 μM (IL-1β)).