176963-46-5

Basic information

• Product Name: 1H-Indole-4-carboxaldehyde, 6-methoxy-7-(methoxymethoxy)-1-(phenylmethyl)-
• CAS NO: 176963-46-5
• Molecular Formula: C19H19NO4
• Molecular Weight: 325.364
• Mol File: 176963-46-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole-4-carboxaldehyde, 6-methoxy-7-(methoxymethoxy)-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-4-carboxaldehyde, 6-methoxy-7-(methoxymethoxy)-1-(phenylmethyl)-(176963-46-5)
• EPA Substance Registry System: 1H-Indole-4-carboxaldehyde, 6-methoxy-7-(methoxymethoxy)-1-(phenylmethyl)-(176963-46-5)

Safety Data

• Hazardous Substances Data: 176963-46-5(Hazardous Substances Data)

Upstream product

• 176963-44-3 1-Benzyl-6-methoxy-7-methoxymethoxy-1H-indole-4-carboxylic acid methyl ester 
• 176963-40-9 methyl 4-benzyloxy-5-methoxy-2-methyl-3-nitrobenzoate 
• 176963-39-6 4-benzyloxy-5-methoxy-2-methyl-3-nitrobenzoic acid 
• 176963-37-4 4-hydroxy-5-methoxy-2-methyl-3-nitrobenzaldehyde 
• 42044-81-5 4-hydroxy-5-methoxy-2-methylbenzaldehyde 
• 1195-09-1 5-methyl-2-methoxyphenol 
• 1027287-47-3 (1-Benzyl-6-methoxy-7-methoxymethoxy-1H-indol-4-yl)-methanol 
• 176963-41-0 methyl 7-benzyloxy-6-methoxyindole-4-carboxylate 
• 176963-38-5 4-benzyloxy-5-methoxy-2-methyl-3-nitrobenzaldehyde 

Downstream Products

• 1027270-94-5 (E)-3-(1-Benzyl-6-methoxy-7-methoxymethoxy-1H-indol-4-yl)-2-methyl-acrylic acid 
• 1027162-41-9 (E)-3-(1-Benzyl-6-methoxy-7-methoxymethoxy-1H-indol-4-yl)-2-methyl-acrylic acid ethyl ester 

Relevant articles and documents

Hydroxyindole derivatives as inhibitors of IL-1 generation. II. Synthesis and pharmacological activities of (E)3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives

A series of (E)-3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives was prepared and the inhibitory activities of its members on IL-1 generation were evaluated in an in vitro system using exudate cells from the rat carboxy-methyl cellulose (CMC) induced air-pouch model. All the compounds in this new series were found to be inhibitors of IL-1 generation. In particular, the methoxy-substituted 2-phenyl compounds 28d-f were the most potent inhibitors of IL-1 generation (eg, 28d: IC50 = 0.8 μ,M). The compounds in this series also inhibited IL-1α and IL-1β generations in an in vitro system using human monocytes stimulated with LPS (eg, 28b: IC50 = 1.4 μM (IL-1α) and 0.9 μM (IL-1β)).