176965-84-7

Upstream product

• 108-24-7 acetic anhydride 
• 176965-83-6 (3R,4S,5R,6R)-3,4,5,6-Tetrahydroxy-cyclohex-1-enecarbonitrile 
• 176965-82-5 (1S,4R,5R,6R)-4,5-Dihydroxy-7-oxa-bicyclo[4.1.0]hept-2-ene-3-carbonitrile 
• 138769-96-7 (5S,6R)-5,6-dihydroxycyclohexa-1,3-dienecarbonitrile 

Downstream Products

• 176965-85-8 Acetic acid (1R,2S,3R,5S,6R)-2,3,6-triacetoxy-5-cyano-cyclohexyl ester 

Relevant academic research and scientific papers

Enantiospecific synthesis of cyanocyclitols and (6R)-6-hydroxyshikimic acid from benzonitrile

The chiral cis-3-cyanocyclohexa-3,5-diene-1,2-diol 5, available by microbial oxidation of benzonitrile, is the key intermediate used in brief syntheses of the cyanocyclitols 9 and 15, and in the synthesis of 6-hydroxyshikimic acid 20.