176966-49-7

Upstream product

• 99439-87-9 (Z)-4-(phenylmethoxy)-2-butenyl methanesulfonate 
• 174591-35-6 (6S,1'S)-6-methyl-4-(1'-phenylethyl)-1,4-morpholine-2,5-dione 

Downstream Products

• 159247-18-4 (+)-bulgecinine 
• 936845-08-8 (3R,6S,2'R,3'R)-3-(4'-benzyloxy-2',3'-dihydroxybutyl)-6-methyl-4-[(S)-phenethyl]-morpholine-2,5-dione 
• 936845-07-7 (3R,6S,2'S,3'S)-3-(4'-benzyloxy-2',3'-dihydroxybutyl)-6-methyl-4-[(S)-phenethyl]-morpholine-2,5-dione 
• 936845-06-6 3-(3-benzyloxymethyl-oxiranylmethyl)-6-methyl-4-(1-phenyl-ethyl)-morpholine-2,5-dione 
• 178232-05-8 (Z)-(R)-6-Benzyloxy-2-[((S)-2-methoxy-propionyl)-((S)-1-phenyl-ethyl)-amino]-hex-4-enoic acid methyl ester 
• 176966-50-0 (Z)-(R)-6-Benzyloxy-2-((S)-1-phenyl-ethylamino)-hex-4-enoic acid amide 

Relevant academic research and scientific papers

Synthesis of new chiral 1,4-morpholin-2,5-dione derivatives and evaluation as α-glucosidase inhibitors. Part 3

A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from chiral synthons 1 and 2, monolactim ethers derived from l-valine, and the absolute configurations of the new stereocentres were assigned. The substrates investigation be

Stereoselective synthesis of unnatural aminoacids cis-4-hydroxyproline and bulgecinine

A new stereoselective synthesis of both (2R,4R)- and (2S,4S)-4-hydroxy-proline and (+)- and (-)-bulgecinine was performed starting from synthons 1 or 1', respectively. The synthetic route has been established via a novel assisted cleavage of a disubstituted amide in mild conditions and successive stereocontrolled iodocyclization.