176966-81-7

Basic information

• Product Name: (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 176966-81-7
• Molecular Weight: 495.691
• Mol File: 176966-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester(176966-81-7)
• EPA Substance Registry System: (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester(176966-81-7)

Safety Data

• Hazardous Substances Data: 176966-81-7(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 176966-92-0 (4R,5S)-4-Allyl-5-(tert-butyl-diphenyl-silanyloxy)-2-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 176966-77-1 tert-butyl (5S)-5-tert-butyldiphenylsilyloxy-piperidine-2-one-1-carboxylate 
• 176966-78-2 tert-butyl (5S)-5-(tert-butyldiphenylsilyloxy)-3,4-dehydro-piperidine-2-one-1-carboxylate 
• 176966-76-0 (5S)-5-tert-butyldiphenylsilyloxy-piperidine-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 24211-54-9 (S)-5-hydroxypiperidin-2-one 

Downstream Products

• 176966-82-8 (3S,4S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 176966-83-9 (3S,4S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-[2-(2-methoxy-ethoxymethoxy)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis of homochiral piperidine derivatives from S-glutamic acid. Stereoselective 1,4-addition of organocuprates to a Δ3-piperidine-2-one. A paroxetine analogue

Enantiomerically pure S-5-hydroxy-2-piperidinone 4, readily available from S-glutamic acid, serves as a key intermediate for the synthesis of 3,4-trans substituted piperidine derivatives. The substituents in the 4-position are introduced via 1,4-conjugate