1770-48-5

Upstream product

• 4955-82-2 1-cyanothioformanilide 
• 1018672-18-8 C₁₄H₁₁N₃O 
• 1092459-63-6 (Z)-2-anilino-2-[oxido(phenyl)imino]-N-pyridin-2-yl-acetamide 
• 95-54-5 1,2-diamino-benzene 
• 15804-19-0 quinoxaline-2,3-dione 
• 62-53-3 aniline 
• 252005-05-3 5-imino-2-methyl-3-phenyl-oxazolidine-4-thione 

Downstream Products

• 1353219-27-8 3-choro-4-(3-nitrophenyl)-1-(2-((E)-((E)-3(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)azetidin-2-one 
• 1353219-28-9 3-choro-4-(furan-3-yl)-1-(2-((E)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)azetidin-2-one 
• 1353219-29-0 3-choro-4-(4-hydroxy-3-methoxyphenyl)-1-(2-((E)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)azetidin-2-one 
• 1353219-30-3 2-(2-hydroxyphenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1353219-31-4 2-(4-hydroxyphenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1353219-32-5 2-(4-methoxyphenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1353219-33-6 2-(4-chlorophenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1353219-34-7 2-(2-chlorophenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1353219-35-8 2-(4-methylphenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1353219-36-9 2-(4-(dimethylamino)phenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1353219-37-0 2-(3-nitrophenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1353219-38-1 3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)-2-(furan-3-yl)thiazolidin-4-one 
• 1353219-39-2 2-(3-methoxy-4-hydroxyphenyl)-3-(2-((Z)-((E)-3-(phenylimino)-3,4-dihydroquinoxalin-2-(1H)-ylidene)amino)phenyl)thiazolidin-4-one 
• 1352920-35-4 C₂₇H₂₁N₅O 

Relevant academic research and scientific papers

Synthesis, leptospirocidal activity and QSAR analysis of novel quinoxaline derivatives

A simple and efficient method has been developed for the synthesis of series of N-Mannich bases of (E)-3- (phenylimino/4-chlorophenylimino)-2,3- dihydro-1-[(N-substituted piperazinyl) methyl]quinoxaline-2-(1H)-one 3a-f and 4a-f. The requisite 2a and 2b were obtained by reactionbetween quinoxaline-2,3-dione 1 and aniline / p-chloroaniline. These compounds underwent NMannich reaction with various substituted piperazines to yield (title compounds 3a-f and 4a-f respectively. Structures of synthesized compounds were confirmed by spectral studies (IR, 1H NMR, 13C NMR and Mass) and elemental analysis. All the synthesized compounds were screened for in vitro leptospirocidal activty against Leptospira interrogans. The potent compounds 4a, 4b and 4c which showed maximum activity during in vitro studies were subjected to in vivo studies. The inhibitory activity of enzymes carboxypeptidase and transpeptidase, in leptospirosis by the synthesized compounds were determined. 3D-QSAR studies model developed showed the need for more hydrophobic and less steric groups as substituent groups to enhance the in vitro activity.

Synthesis, in vitro antitubercular activity and 3D-QSAR of novel quinoxaline derivatives

Twenty new quinoxalines bearing azetidinone and thiazolidinone groups were synthesized by cyclocondensation of Schiff bases of quinoxaline-2, 3-dione and were characterized with several analytical tools. They were tested against Mycobacterium tuberculosis

New α-amido-α-aminonitrones as building blocks for constructing heterocyclic systems

New, stable α-amido-α-aminonitrones were obtained in good yields from 3-oxobutyric acid N-pyridin-2-ylamides and nitrosobenzene. The α-amido-α-aminonitrones were then used as new, versatile building blocks to obtaining various heterocycles with both bielectrophilic and binucleophilic reagents. With diiodomethane as reagent, 1,2,5-oxadiazine derivatives were formed, whereas reactions with aromatic 1,2-, 1,3- and 1,4-diamines yielded quinoxaline, quinazoline, perimidine, and dibenzo[d,f][1,3]diazepine derivatives, respectively. Georg Thieme Verlag Stuttgart.

Novel syntheses of 3-anilino-pyrazin-2(1H)-ones and 3-anilino-quinoxalin-2-(1H)-ones via microwave-mediated Smiles rearrangement

In this Letter, we report a novel approach to the preparation of 3-anilino-pyrazin-2(1H)-ones and 3-anilino-quinoxalin-2(1H)-ones from the corresponding 3-halo pyrazin-2-amines and 3-haloquinoxalin-2-amines, using a microwave-mediated Smiles rearrangement

A comparative study of 4-thioxo-(imidazolidines and oxazolidines) and some nucleophilic reagents

The imidazolidines (II) were reacted with amines, H2S and ?-phenylenediamines to give 4-substituted imino derivatives (VI), thiohydantoin (VII) and 1-phenyl-3 -substituted-1H-imidazo[4,5-b]-quinoxaline-2-(3H)-ones(XIII), respectively. Interaction of the oxazolidines (V) with amines, ?-phenylenediamines and ?-aminophenol caused fission of the oxazole ring to produce (XIV, XVII & XIX) respectively.