177034-25-2

Basic information

• Product Name: 2,4-Difluoro-5-Methoxybenzaldehyde
• Synonyms: 2,4-Difluoro-5-Methoxybenzaldehyde
• CAS NO: 177034-25-2
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.1288464
• Mol File: 177034-25-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4-Difluoro-5-Methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluoro-5-Methoxybenzaldehyde(177034-25-2)
• EPA Substance Registry System: 2,4-Difluoro-5-Methoxybenzaldehyde(177034-25-2)

Safety Data

• Hazardous Substances Data: 177034-25-2(Hazardous Substances Data)

Usage

General Description

2,4-Difluoro-5-Methoxybenzaldehyde is a chemical compound that belongs to the class of benzaldehydes. It is characterized by its molecular structure, which contains two fluorine atoms and a methoxy group attached to a benzene ring. 2,4-Difluoro-5-Methoxybenzaldehyde is commonly used in the field of organic synthesis and pharmaceutical research, where it serves as an important building block for the production of various chemical intermediates and bioactive molecules. Its unique structure and reactivity make it a valuable reagent for the synthesis of complex organic compounds. Additionally, it is also used in the production of flavors and fragrances. Overall, 2,4-Difluoro-5-Methoxybenzaldehyde plays a crucial role in the development of new chemical entities and has diverse applications in the chemical and pharmaceutical industries.

Upstream product

• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 4885-02-3 Dichloromethyl methyl ether 
• 452-10-8 2,4-difluoro-1-methoxybenzene 

Downstream Products

• 900175-14-6 2-(2,4-difluoro-5-methoxyphenyl)-2-hydroxyacetonitrile 

Relevant articles and documents

Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

The direct, Pd-catalyzed ortho C-H methylation and fluorination of benzaldehydes have been accomplished using commercially available orthanilic acids as transient directing groups. In these reactions, the 1-fluoro-2,4,6-trimethylpyridinium salts can be either a bystanding F+ oxidant or an electrophilic fluorinating reagent. An X-ray crystal structure of a benzaldehyde ortho C-H palladation intermediate was obtained using triphenylphosphine as the stabilizing ligand.

PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS

The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.