177087-38-6Relevant articles and documents
Reduction of cyclic maleic acid derivatives
Stachel, Hans-Dietrich,Schachtner, Josef,Seidel, Josef
, p. 409 - 416 (2007/10/03)
A series of potentially cytotoxic αβ-unsaturated γ-hydroxy-butyrolactones, -lactams and -thiolactones has been synthesized via regioselective hydride reduction of the appropriate maleic acid anhydrides, imides and thioanhydrides. By this means a straightforward access to naturally occurring antibiotic narthigenine 2, its hitherto unknown thio-analogue 5b and higher substituted derivatives and analogues of 2 is presented.