17710-00-8

Basic information

• Product Name: ethyl (3-chloroanilino)(oxo)acetate
• Synonyms: ethyl (3-chloroanilino)(oxo)acetate
• CAS NO: 17710-00-8
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.6443
• Mol File: 17710-00-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl (3-chloroanilino)(oxo)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (3-chloroanilino)(oxo)acetate(17710-00-8)
• EPA Substance Registry System: ethyl (3-chloroanilino)(oxo)acetate(17710-00-8)

Safety Data

• Hazardous Substances Data: 17710-00-8(Hazardous Substances Data)

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 108-42-9 3-chloro-aniline 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 

Downstream Products

• 72296-01-6 N-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-N'-(3-chloro-phenyl)-oxalamide 
• 53117-26-3 N-<3-Chlor-phenyl>-oxaminsaeure-hydrazid 
• 57864-87-6 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid 3-chloro-anilide 

Relevant articles and documents

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers

A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key intermediates ethyl 1-aryl-1H-tetrazole-5-carboxylates 10 can be simply and efficiently prepared via a microwave-assisted continuous operation process. Among the compounds synthesised, compound 6–31 showed noteworthy potency against SGC-7901, A549 and HeLa cell lines. In mechanism studies, compound 6–31 inhibited tubulin polymerisation and disorganised microtubule in SGC-7901 cells by binding to tubulin. Moreover, compound 6–31 arrested SGC-7901cells in G2/M phase. This study provided a new perspective for development of antitumor agents that target tubulin.

A transformation of N-alkylated anilines to N-aryloxamates

Transformation of N-alkylated anilines to N-aryloxamates was studied using ethyl 2-diazoacetoacetate as an alkylating agent and dirhodium tetraacetate (Rh2(OAc)4) as the catalyst. The general applicability of the reaction as a synthetic method for N-aryloxamates was studied with a number of substituted N-alkylated anilines. The results revealed that the oxamate was formed by a radical reaction with molecular O2 and Rh 2(OAc)4 as initiator. Copyright

Oxanilic acids and derivatives

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