177167-05-4

Basic information

• Product Name: BUTTPARK 144\07-82
• Synonyms: BUTTPARK 144\07-82;6-BROMO-2-CHLOROMETHYL-QUINAZOLIN-4-OL;6-BroMo-2-chloroMethyl-1H-quinazolin-4-one;6-Bromo-2-(Chloromethyl)Quinazolin-4(3H)-One(WX130205)
• CAS NO: 177167-05-4
• Molecular Formula: C₉H₆BrClN₂O
• Molecular Weight: 273.51
• Mol File: 177167-05-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 240-242 °C
• Boiling Point: 404.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.83±0.1 g/cm3(Predicted)
• PKA: -0.38±0.20(Predicted)
• CAS DataBase Reference: BUTTPARK 144\07-82(CAS DataBase Reference)
• NIST Chemistry Reference: BUTTPARK 144\07-82(177167-05-4)
• EPA Substance Registry System: BUTTPARK 144\07-82(177167-05-4)

Safety Data

• Hazardous Substances Data: 177167-05-4(Hazardous Substances Data)

Upstream product

• 107-14-2 chloroacetonitrile 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 155104-20-4 N-chloroacetyl-5-bromoanthranilic acid 
• 177166-98-2 6-bromo-2-(chloromethyl)-4H-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition

Aurora A kinase, a member of the Aurora kinase family, is frequently overexpressed in various human cancers. In addition, Overexpression of Aurora A kinase is associated with drug resistance and poor prognosis in many cancers including breast cancer. Therefore, Aurora A kinase has been considered as an attractive anticancer target for the treatment of human cancers. Herein, A series of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives were designed, synthesized, and evaluated as Aurora A kinase inhibitors. The cell-based cytotoxicity assays showed that compound 16h was the most potent cytotoxic agent against all tested cancer cells and had a lower IC50 value than ENMD-2076 against MDA-MB-231 cells. Meanwhile, Aurora A kinase assay and Western blot analysis showed that 16h inhibited Aurora A kinase with an IC50 value of 21.94 nM and suppressed the phosphorylation of Histone H3 on Ser10 and Aurora A kinase on Thr288, which were consistent with the activation of Aurora A kinase. Accordingly, 16h caused aberrant mitotic phenotypes and obvious G2/M phase arrest in MDA-MB-231 cells and induced caspase-dependent apoptosis in MDA-MB-231 cells. These results demonstrated that 16h is a potential candidate for the development of anticancer agents targeting Aurora A kinase.

Pyrido imidazole substituted quinazolinone derivative as well as synthesis method and application thereof

The invention discloses a pyridazole substituted quinazolinone derivative, and the structural formula thereof is as follows. The invention also discloses a synthetic method thereof. The pyrido-imidazole-substituted quinazolinone derivative can induce high

QUINAZOLINE BASED RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I), wherein R1, R2, R3, R4 and n are defined herein, are useful as inhibitors of RSV.