177174-55-9

Basic information

• Product Name: (2-Hydroxy-5-trifluoromethoxy-phenyl)-pyridin-2-yl-methanone
• CAS NO: 177174-55-9
• Molecular Weight: 283.207
• Mol File: 177174-55-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-Hydroxy-5-trifluoromethoxy-phenyl)-pyridin-2-yl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Hydroxy-5-trifluoromethoxy-phenyl)-pyridin-2-yl-methanone(177174-55-9)
• EPA Substance Registry System: (2-Hydroxy-5-trifluoromethoxy-phenyl)-pyridin-2-yl-methanone(177174-55-9)

Safety Data

• Hazardous Substances Data: 177174-55-9(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 129644-57-1 TFMSA 

Relevant articles and documents

Synthesis and biological activity of novel 1,3-benzoxazine derivatives as K+ channel openers

A new series of 1,3-benzoxazine derivatives with a 2-pyridine 1-oxide group at C4 was designed to explore novel K+ channel openers. Synthesis was carried out by using a palladium(0)-catalyzed carbon-carbon bond formation reaction of imino-triflates with organozinc reagents and via a new one-pot 1,3-benzoxazine skeleton formation reaction of benzoylpyridines. The compounds were tested for vasorelaxant activity in tetraethylammonium chloride (TEA) and BaCl2-induced and high KCl-induced contraction of rat aorta to identify potential K+ channel openers, and also for oral hypotensive effects in spontaneously hypertensive rats. An electron- withdrawing group with the proper shape at C6 and a methyl or halogens group at C7 of the 1,3-benzoxazine nucleus were required for the development of optimal vasorelaxant and hypotensive activity. In particular, 2-(6-bromo-7- chloro-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)pyridine 1-oxide (71) showed more potent vasorelaxant activity (EC50=0.14 μM) against TEA and BaCL2- induced contraction and longer-lasting hypotensive effects than cromakalim (1).