17719-28-7Relevant academic research and scientific papers
New process for the synthesis of acylsulfonamides derivatives
-
Paragraph 0041-0044, (2018/05/29)
The present invention refers to the treatment of Alzheimer's diseases such as necessary or useful as an intermediate for pharmaceuticals for merging, joining a selectively N - acylated reaction include specific method relates to useful as intermediates for the synthesis of the opinion phone which will know probably the id, carboxyl group activated carboxyl group number are previous method using a long time after the opinion phone which will know probably the id [...] and activate the heating reacting synthesizing either harsh reaction conditions, which does not direct use of organic acid anhydride [...] shape after reacting fatal door perfect point of which the number in order to solve gun [su [su] [ceyn] 5 to 25 degrees [...] organic base and organic acid [sep [sep] city mild reaction conditions in the presence of tree also reacting time 1 in high yield and purity can be short response times in the inside and outside of the opinion phone which will know probably the id number number [...] method by a high pressure liquid coolant, medicinal and their need in the field of power generation significantly contribute to pathogenic zymotic techniques and related intermediates are disclosed. (by machine translation)
An improved practical synthesis of protected α-amino selenocarboxylates and its application to the synthesis of N-(α-aminoacyl)sulfonamides
Wu, Xinghua,Chen, Yu,Hu, Longqin
scheme or table, p. 5585 - 5588 (2011/02/22)
An improved practical synthetic method was developed for the preparation of selenocarboxylates of amino acids through the reaction of the corresponding activated esters with sodium hydrogen selenide in alcoholic or aqueous medium. The protected α-amino se
Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group
Amssoms, Katie,Oza, Sandra L.,Ravaschino, Esteban,Yamani, Abdellah,Lambeir, Anne-Marie,Rajan, Padinchare,Bal, Gunther,Rodriguez, Juan Bautista,Fairlamb, Alan H.,Augustyns, Koen,Haemers, Achiel
, p. 2553 - 2556 (2007/10/03)
Glutathionylspermidine synthetase/amidase (GspS) is an essential enzyme in the biosynthesis and turnover of trypanothione and represents an attractive target for the design of selective anti-parasitic drugs. We synthesised a series of analogues of glutathione (L-γ-Glu-L-Leu-Gly-X) where the glycine carboxylic acid group (X) has been substituted for other acidic groups such as tetrazole, hydroxamic acid, acylsulphonamide and boronic acid. The boronic acid appears the most promising lead compound (IC50 of 17.2 μM).
