177210-25-2

Usage

Derivative of indole

A modified version of the indole structure, which is a heterocyclic aromatic organic compound.

Heterocyclic aromatic compound

A compound containing a ring of atoms with at least one atom being different from carbon (in this case, nitrogen), and having delocalized electrons across the ring, giving it aromatic properties.

Bromomethyl group

A functional group consisting of a bromine atom bonded to a carbon atom, which is part of the 1H-Indole structure in 1H-Indole, 4-(bromomethyl)-1-(phenylsulfonyl)-.

Phenylsulfonyl group

A functional group consisting of a sulfur atom double-bonded to a phenyl group, which is also part of the 1H-Indole structure in 1H-Indole, 4-(bromomethyl)-1-(phenylsulfonyl)-.

Synthetic chemical compound

A compound that is artificially created through chemical reactions, rather than being found naturally in nature.

Common use in chemical research and organic synthesis

1H-Indole, 4-(bromomethyl)-1-(phenylsulfonyl)- is frequently used as a building block or reagent in various chemical reactions and studies to synthesize other compounds or investigate reaction mechanisms.

Potential applications in pharmaceuticals and agrochemicals

The compound may be used as an active ingredient or intermediate in the development of drugs and agrochemicals, such as pesticides or herbicides.

Exhibits different biological activities

The compound may interact with biological systems, such as enzymes, proteins, or cells, and produce various effects, making it of interest for medical and biochemical studies.

Hazardous properties and safe handling

Due to its potentially hazardous nature, it is crucial to handle 1H-Indole, 4-(bromomethyl)-1-(phenylsulfonyl)- with caution and in a controlled, safe environment to minimize risks associated with its use.

Upstream product

• 558-13-4 carbon tetrabromide 
• 177210-24-1 (1-benzenesulfonyl-1H-indol-4-yl)-methanol 
• 146564-06-9 4-methyl-1-phenylsulfonyl-1H-indole 

Downstream Products

• 1009375-42-1 4-benzyl-1-(phenylsulfonyl)-1H-indole 
• 1184953-75-0 1-benzenesulfonyl-4-(1,4-dioxaspiro[4.5]dec-8-ylmethoxymethyl)-1H-indole 
• 146073-06-5 1-(benzenesulphonyl)-1H-indole-4-carboxaldehyde 
• 856111-26-7 1-benzenesulfonyl-4-phenylsulfanylmethyl-1H-indole 

Relevant academic research and scientific papers

Substituted 4-aminocyclohexane derivatives

Substituted 4-aminocyclohexane derivatives having the formula I: [image] wherein R1-R4 are as described herein, methods for their preparation, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted 4-amino

INDOLES AS 5-HT6 MODULATORS

The present invention relates to novel compounds of formula (I) wherein m, n, R0, R1, R2, R3 and R4 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for t

Unusual dimerization of N-protected bromomethylindoles/benzyl bromide with arylmetal halides: generation of indolylmethyl/benzyl radical

A detailed study on the interaction of N-protected bromomethylindoles with various types of aryl/alkyl Grignard is reported. Full experimental details on the mechanism of the unusual dimerization reaction are presented.

Synthesis of N-protected indolaldehydes using modified Hass procedure

A detailed study on oxidation of N-protected bromomethylindoles into the respective aldehydes was carried out. Using a modified Hass procedure, synthesis of aryl-/hetero-aryl aldehydes in particular indolaldehydes is achieved in reasonable yields.

NOVEL TETRAYDROSPIRO{PIPERIDINE-2,7’ -PYRROLO[3,2-b]PYRIDINE DERIVATIVES AND NOVEL INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF 5-HT6 RECEPTOR -RELATED DISORDERS

The present invention relates to compounds of formula (I): Formula (I) wherein U, P, W1, W2, W3, v, Y, Z, Rm, and Rm’ are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.

Unusual dimerization of N-protected bromomethylindoles using phenylmagnesium chloride

A novel dimerization of N-protected bromomethylindoles involving an exchange reaction with phenylmagnesium chloride is reported.

Stille carbonylation of N-protected bromomethylindoles

A variety of N-protected indolylmethylbromides are carbonylated using 5 mol % Pd(PPh3)2Cl2 under Stille conditions in the presence of an alcohol to afford the corresponding methyl/ethyl esters.

A facile preparation of N-protected indolaldehydes using a modified Hass procedure

The preparation of a variety of N-protected indolaldehydes is reported via the reaction of N-protected bromomethylindoles with 2-nitropropane using NaH/DMF.

An efficient preparation of 1-phenylsulfonylindolyl methyl sulfoxides using KF/m-CPBA

A variety of 1-phenylsulfonylindolylmethyl sulfides are selectively oxidized to the corresponding sulfoxides using a hitherto unexplored KF/m-CPBA system. A major advantage is the absence of over-oxidation.

Preparation of benzindole compounds from naphthalene compounds

The invention relates to a process for preparing a substituted 2-amino-benz[cd]indole of the Formula I: STR1 The nitro group of a substituted 1-nitro-8-cyano-naphthalene compound is reduced to an amine group to form a substituted 1-amino-8-cyano-naphthalene compound, which is cyclized to form the substituted 2-amino-benz[cd]indole. The reduction and cyclization may be effected in a one-pot procedure using a reducing agent such as stannous chloride, which generates an acid that cyclizes the reduction product. The syntheses of the 1-nitro-8-cyanonaphthalene compound and its precursors are also described.