17725-02-9

Upstream product

• 2078-54-8 2,6-diisopropylphenol 

Downstream Products

• 1246886-34-9 C₂₇H₄₈ClO₄P 
• 1246886-36-1 C₄₃H₇₆ClO₇P 
• 1246886-31-6 2,6-diisopropylphenyldodecylhydrogenphosphate 
• 1246886-32-7 C₂₆H₄₄ClO₅P 
• 21255-02-7 Phosphorsaeure-(2,6-diisopropylphenylester)-bis-benzylamid 
• 18351-38-7 2,6-diisopropylphenyl dihydrogen phosphate 

Relevant academic research and scientific papers

PROPOFOL PHOSPHONYL DERIVATIVES, SYNTHESIS, AND USE IN LONG ACTING FORMULATIONS

This invention relates to compounds represented by the structural formula (I), and the salts and stereoisomers thereof, wherein: - L is a linker selected from the group consisting of -(CH2)P-O-, a single bond, formula (IA), -(CH2)1-8-O-X(O)-, and - p is an integer from 1 to 8, - each R3 and each R4 is independently selected from the group consisting of C1-20alkyl, C3-12alkyl, C3-12cycloalkyl-C1-4alkyl, saturated heterocyclyl and saturated heterocyclyl-C1-4alkyl, and - X and Y are each independently C or S(O), - Z is selected from the group consisting of O, S(O) and NR5, - W is selected from the group consisting of halogen, OH, S(O)H and O-M+ wherein M+ is a monovalent cation; and - R5 is selected from the group consisting of hydrogen and C1-10 alkyl. These compounds are useful pharmaceutical agents with improved oral bioavailability.

KINETICS OF ESTERIFICATION OF DIISOPROPYLPHENOLS WITH PHOSPHORYL TRICHLORIDE

The title liquid-phase isothermal esterification kinetics have been measured in the temperature intervals of 110-125 and 110-160 deg C for 2,4- and 2,6-diisopropylphenols, resp.The values measured have been used to calculate the rate constants of the respective three steps and to determine the activation energies. 2,6-Diisopropylphenol has been found to react only to the first degree, and the rate constants of the other two reaction steps (k2, k3) were only calculated from the differential equations given by means of a computer.