177255-09-3Relevant academic research and scientific papers
SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL ACTIVATORS
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Paragraph 0525-0526, (2021/03/05)
Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
Evaluation of the NO-releasing properties of NO-donor linkers
Calderone, Vincenzo,Digiacomo, Maria,Martelli, Alma,Minutolo, Filippo,Rapposelli, Simona,Testai, Lara,Balsamo, Aldo
, p. 189 - 195 (2008/09/20)
This work describes the synthesis of some benzoic (1-4) and alcoholic (5-7) nitrooxy derivatives, which are nitric oxide (NO) donors in themselves, and can also be seen as useful linkers that can be used in multi-target drugs capable of releasing NO. The
