177264-57-2Relevant academic research and scientific papers
QUINOXALINE COMPOUNDS AND USES THEREOF
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Page/Page column 24-25; 37, (2012/06/15)
Disclosed herein are compounds of formula (I) and methods of inhibiting ΙΚΚβ and the NF-κB signaling and mTOR pathways.
Perturbing pro-survival proteins using quinoxaline derivatives: A structure-activity relationship study
Rajule, Rajkumar,Bryant, Vashti C.,Lopez, Hernando,Luo, Xu,Natarajan, Amarnath
, p. 2227 - 2234 (2012/06/01)
In HeLa cells the combinatorial knockdown of Bcl-xL and Mcl-1 is sufficient to induce spontaneous apoptosis. Quinoxaline derivatives were screened for the induction of Mcl-1 dependent apoptosis using a cell line without functional Bcl-xL. Quinoxaline urea
2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure-activity relationship study
Chen, Qianyi,Bryant, Vashti C.,Lopez, Hernando,Kelly, David L.,Luo, Xu,Natarajan, Amarnath
, p. 1929 - 1932 (2011/04/24)
The quinoxaline core is considered a privileged scaffold as it is found in a variety of biologically relevant molecules. Here we report the synthesis of a quinoxalin-6-amine library, screening against a panel of cancer cell lines and a structure-activity
