177326-60-2Relevant academic research and scientific papers
Synthesis and cytotoxic activity of new 9-substituted camptothecins
Dallavalle, Sabrina,Rocchetta, Daniela Granza,Musso, Loana,Merlini, Lucio,Morini, Gabriella,Penco, Sergio,Tinelli, Stella,Beretta, Giovanni Luca,Zunino, Franco
, p. 2781 - 2787 (2008/12/22)
A series of novel 9-substituted camptothecins derived from 9-formylcamptothecin were synthesized. The aldehyde was obtained from 10-hydroxycamptothecin or, better, by total synthesis. The compounds showed antiproliferative activity higher than that of the
Convenient synthesis of fragment E of antibiotic, nosiheptide
Shin, Chung-Gi,Yamada, Yasuhiro,Hayashi, Keiichiro,Yonezawa, Yasuchika,Umemura, Kazuyuki,Tanji, Tsuyoshi,Yoshimura, Juji
, p. 891 - 898 (2007/10/03)
A convenient synthesis of Fragment E, 4-hydroxymethyl-3-methylindole-2-earboxylic acid (1), from 2-methyl-3-nitrobenzyl alcohol through six steps conversion in 32 % overall yield is described.
