17734-22-4

Upstream product

• 894356-84-4 7-Phenyl-heptylazide 
• 3208-25-1 7-phenylheptan-1-ol 
• 151921-82-3 2-(7-phenylheptyl)isoindoline-1,3-dione 
• 127611-48-7 ((1E,3Z)-7-Azido-hepta-1,3-dienyl)-benzene 
• 157735-29-0 N-(7-oxo-7-phenylheptyl)phthalimide 
• 107416-06-8 7-phenyl-heptanoic acid amide 
• 78573-85-0 1-bromo-7-phenyl-heptane 

Downstream Products

• 102708-59-8 DL-N-Pantoyl-7-phenyl-heptylamin 
• 39520-64-4 7-phenylheptanenitrile 
• 98510-44-2 6-<(7-phenylheptyl)amino>-5-nitrosoisocytosine 
• 1415221-86-1 N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoic acid 
• 1415221-96-3 benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate 

Relevant academic research and scientific papers

Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)

We report herein that incorporating long-chain alkylphenyl-containing non-proteinogenic amino acids in place of His at the pT-2 position of the parent polo-like kinase 1 (Plk1) polo box domain (PBD)-binding pentapeptide, PLHSpT (1a) increases affinity. Fo

Derivatives of squaric acid with anti-proliferative activity

The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable sa

Derivatives of squaric acid with anti-proliferative activity

The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof.

ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS

The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.

Cyanoguanidines as cell proliferation inhibitors

The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine being in the 3- or 4-position, in which formula R1 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl nitro, amino, cyano, carboxy, or alkyl, alkoxy, or alkoxycarbonyl, the C-content of which can be from 1 to 4; X stands for a straight or branched C9-C20 carbon chain, saturated or unsaturated or Q—Ar—R; in which formula Ar stands for phenyl, Q stands for a C5-C20 divalent hydrocarbon radical which can be straight, branched, saturated or unsaturated and R stands for hydrogen or for one or more substituents which can be the same or different and are selected from the group consisting of: hydroxy, amino, halogen, trifluoromethyl, cyano, nitro, carboxy, carbamoyl, or alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 4; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.

Unusually Long Lifetimes of the Singlet Derived from 4-Azido-2,3,5,6-tetrafluorobenzamides

Laser flash photolysis (308 nm, 20 ns, 150 mJ) of 4-azido-2,3,5,6-tetrafluorobenzamides, esters, and thioesters generate singlet nitrenes which can be intercepted with pyridine to produce strongly absorbing ylides.It was possible to resolve the rate of formation of the ylides as a function of pyridine concentration.This has lad to direct measurements of the absolute rate constants of (a) the reaction of the nitrene with pyridine, (b) ring expansion of the nitrene to a ketenimine, and (c) singlet to triplet nitrene intersystem crossing.

Stereospecific synthesis of Z olefins bearing an ω-azido group.

Ylides derived from ω-azidoalkyltriphenylphosphonium salts were generated at low temperature.They are stable at -80 deg C for several hours and react smoothly and stereospecifically with typical aldehydes to form Z-ω-azido olefins which are the precursors of ω-unsaturated primary and secondary amines.