177355-84-9 Usage
Uses
Used in Cancer Research:
DBeQ is used as a research tool for studying the role of ATPase p97 in cancer cells. It is employed to block endoplasmic reticulum-associated degradation, impair the autophagy pathway, and promote the activation of caspase-3 and -7 in cancer cells.
Used in Cellular Processes Research:
DBeQ is used as a research tool for studying various cellular processes that require unfolding and disassembly of protein complexes, as ATPase p97 plays a critical role in these processes.
Used in HeLa Cell Studies:
DBeQ is used as a treatment for HeLa cells to study the effects on in vivo ubiquitination and protein dislocation by live cell imaging.
Biochem/physiol Actions
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
References
1) Chou et al. (2011), Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proc. Natl. Acad. Sci. USA, 108 4834
Check Digit Verification of cas no
The CAS Registry Mumber 177355-84-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,3,5 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 177355-84:
(8*1)+(7*7)+(6*7)+(5*3)+(4*5)+(3*5)+(2*8)+(1*4)=169
169 % 10 = 9
So 177355-84-9 is a valid CAS Registry Number.
177355-84-9Relevant academic research and scientific papers
New synthesis of substituted 4-amino-quinazolines and their heteroanaloga
Gewald,Schaefer,Eckert,Jeschke
, p. 206 - 213 (2007/10/03)
N-Chloracetyl-anthranilonitriles react with potassium thiocyanate in the presence of alcohol to the (4-amino-quinazolin-2-yl-thio)-acetic acid ester (5). In the presence of water or primary amine the acetic acid derivative (6) or the acetic acid amide derivatives (7) are obtained. 2,4-Diaminoquinazolines (8) arise if vigorous reaction conditions are employed. With 2-chloracetylamino-cyclopent-1-en-carbonitrile as starting material the pyrimidines (11) are formed from the reaction with potassium thiocyanate. Analogously, (4-pyrimidyl-2-yl-seleno)-acetic acid ester (12) and (thiazolo[4,5-d]pyrimid-2-yl-seleno)-acetic acid derivatives (16) can be prepared with potassium selenocyanate. N-Chloracetyl derivatives of 5-membered heterocycles with enamino-nitrile structure (13, 15, 18, 20) react with potassium thiocyanate to yield thieno[2,3-d]-, thiazolo[4,5-d]-, pyrrolo[2,3-d]-, furo[2,3-d]-and pyrazolo[4,3-d]pyrimidines (14, 16, 19a, 19b, 21). Johann Ambrosius Barth 1996.
