177364-50-0Relevant academic research and scientific papers
Ternary nanoclusters of CuHgS, CuHgSe, and CulnS
Tran, Diem T. T.,Beltran, Lianne M. C.,Kowalchuk, Collin M.,Trefiak, Nicholas R.,Taylor, Nicholas J.,Corrigan, John F.
, p. 5693 - 5698 (2002)
Two copper-mercury-chalcogenide clusters [Hg15Cu20E25(PPr3)18] (1, E = S; 2, E = Se) are synthesized in good yield from the reaction of (Pr3P)3Cu-ESiMe3 and (Pr3P)2·Hg(OAc)2 at low temperatures. Single-crystal X-ray analyses illustrate that the two ternary clusters are isomorphous and consist of a phosphine-stabilized core of mixed Hg, Cu, and E centers. Thermolysis of 1 leads to the formation of mercury metal and various forms of copper-sulfide. The copper-indium-sulfide cluster [Cu6In8S13Cl4 (PEt3)12] (3) is similarly prepared in 50% yield from (Et3P)3Cu-SSiMe3, InCl3, and S(SiMe3)2.
2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith
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, (2008/06/13)
The present invention provides a pharmaceutical composition for treating ulcerative colitis containing at least one compound of the general formula: STR1 wherein X is an --SO2 -- or --CO-- group and R is either an unsubstituted or substituted non-heterocyclic aromatic ring system or is a radical of the general formula --(CH2)n --Y, in which Y is a hydroxyl group, an unsubstituted or substituted amino group or a carboxylic or sulphonic acid group and n is a whole number of from 1 to 6 and in which one or more hydrogen atoms in the alkylene radical can be replaced by unsubstituted or substituted amino groups or alkyl radicals and in which the --(CH2)n --Y radical is either attached directly to the nitrogen atom or via a benzene ring; and/or containing at least one ester thereof and/or at least one non-toxic, pharmaceutically acceptable salt thereof, in admixture with a solid or liquid pharmaceutical diluent or carrier. Furthermore, the present invention provides a process for preparing the compounds of the above-given general formulae and also provides a method of treating ulcerative colitis.
Δ1 -1-Azacycloalkene-2-carboxylic acids and their production
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, (2008/06/13)
A compound of the formula STR1 or a salt thereof, OR OF THE FORMULA STR2 OR A SALT THEREOF, WHEREIN R1 and R2 are the same or different and each is hydrogen, lower alkyl, cycloalkyl of 4 to 7 carbon atoms, aryl of 6 to 14 carbon atoms, or aralkyl of up to 18 carbon atoms wherein the alkyl moiety contains up to 6 carbon atoms; and n is 3, 4 or 5; Is produced by hydrolyzing a compound of the formula STR3 wherein R1, R2 and n are as above defined, and X is halogen; A compound of the formula STR4 or a hydrohalide thereof, wherein R1, R2, n and X are as above defined; or A compound of the formula STR5 wherein R1, R2, n and X are as above defined; In the presence of a base at a temperature of from about 20° to about 180° C. The compounds produced are valuable intermediates from which cyclic amino acids and α,ω-diaminocarboxylic acids are obtained.
