177366-31-3

Upstream product

• 29304-40-3 2-methyl-3-oxohexanoic acid ethyl ester 
• 609-14-3 2-acetylpropanoic acid ethyl ester 

Downstream Products

• 177366-32-4 2-(2-Benzyloxy-ethyl)-3-ethyl-6-methoxy-5-methyl-pyran-4-one 
• 134332-63-1 Phenoxan 
• 177366-41-5 3-Ethyl-6-methoxy-5-methyl-2-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-4,5-dihydro-oxazol-4-yl]-pyran-4-one 
• 1027322-60-6 (E)-4-Methyl-5-phenyl-pent-4-enoic acid [1-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-hydroxy-ethyl]-amide 
• 177366-35-7 (E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-hydroxy-ethyl ester 
• 177366-36-8 (E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester 
• 177366-40-4 (E)-4-Methyl-5-phenyl-pent-4-enoic acid [2-(tert-butyl-dimethyl-silanyloxy)-1-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-ethyl]-amide 

Relevant academic research and scientific papers

Total synthesis of phenoxan and a related pyrone derivative

Phenoxan, HIV-1 inhibitor isolated from the myxobacteria, has been synthesized in 16 steps starting from ethyl 2-methylacetoacetate. The related isomer corresponding to the oxazole part was also obtained via an orthoester-enediol rearrangement.