1774-04-5Relevant academic research and scientific papers
Method for preparing 4-cyclohexylmorpholine compound by using lignin model compound
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Paragraph 0075-0079, (2021/01/24)
The invention discloses a method for preparing a 4-cyclohexylmorpholine compound by using a lignin model compound, which is characterized by comprising the following steps: respectively dissolving thelignin model compound and a morpholine ether amine compound in a m-xylene solution, and carrying out coupling reaction in the presence of a Pd/C catalyst in a hydrogen atmosphere to prepare a 4cyclohexyl morpholine derivative and a derivative thereof, wherein the Pd/C catalyst is mixed with a lignin model compound, a morpholine ether amine compound and m-xylene according to a ratio of 1 mmol: 16-34 mmol: 25-50 mmol: 50-100 ml based on Pd, a stirring reaction is performed for 6-12 h at a temperature of 90-150 DEG C, a reaction liquid is cooled to a room temperature, and filtration is performedto prepare the 4-cyclohexyl morpholine compound. Compared with the prior art, the method has the advantages that the raw materials are easy to obtain, the production cost is low, the use of a heavy metal reagent is avoided, and the method is a green, environment-friendly, economical and efficient method for directly and efficiently preparing the 4-cyclohexylmorpholine and the derivative thereof by utilizing the aromatic ether.
