17744-50-2Relevant academic research and scientific papers
Antibacterial evaluation and molecular docking studies of pyrazole–thiosemicarbazones and their pyrazole–thiazolidinone conjugates
Ebenezer, Oluwakemi,Singh-Pillay, Ashona,Koorbanally, Neil A.,Singh, Parvesh
, p. 191 - 204 (2020/03/11)
A library of pyrazole–thiazolidinone conjugates was synthesized using a molecular hybridization approach through a Vilsmeier–Haack reaction. The compounds were tested for anti-microbial activity against two Gram-positive bacteria (Staphylococcus aureus and methicillin-resistant Staphylococcus aureus) and four Gram-negative bacteria (Escherichia coli, Salmonella typhimurium, Klebsiella pneumonia and Pseudomonas aeruginosa). Among the compounds tested, 3-((2,4-dichlorophenyl)-1-(2,4-dinitrophenyl)-1H-pyrazol-yl)methylene)hydrazinecarbothioamide (3a) and 2-((3-(2-chlorophenyl)-1-(2,4 dinitrophenyl)-1H-pyrazol-4-yl)methyleneamino)thiazolidin-4-one (4b) emerged as the most potent anti-microbial compounds with minimum bactericidal concentrations of 0.2?μM against MRSA and S. aureus. Structure–activity relationship analysis further revealed that the presence of 2,4-dichloro moiety surprisingly influenced the activity of the compounds. Molecular docking studies of the compounds into the crystal structure of topoisomerase II and topoisomerase IV suggest that compounds 3a and 4b preferably interact with the targets through hydrogen bonding.
Synthesis and characterization of hydrazone and azine derivatives of bis(cyclopentadienyI) titanium(IV)
Kaushik, Narender Kumar,Khera, Brij,Sharma, Anand Kumar
, p. 793 - 794 (2021/11/22)
Pentacoordinated hydrazone and azine derivatives of bis(cyclopentadienyl)titanium(IV) of the type {equation presented}, have been prepared. The products were characterized by chemical analyses, elec- trical conductance, IR, 1H NMR, and electronic spectral studies. Some hydrazone complexes and a few azine com- plexes of titanium have been studied.' ' However, no systematic study on their organometallic derivatives is available. In view of the versatile chelating ability, widespread applications and lack of data involving organometallic derivatives of titanium, it has been considered of interest to study the reactions of Cp2TiCl2 with the title ligands.
Synthesis and Characterization of Hydrazone and Azine Derivatives of Bis(cyclopentadienyl)titanium(IV)
Khera, Brij,Sharma, Anand Kumar,Kaushik, Narender Kumar
, p. 793 - 794 (2007/10/02)
Pentacoordinated hydrazone and azine derivatives of bis(cyclopentadienyl)titanium(IV) of the type and , where R=H or CH3, R'=H, C6H5 or C6H3(NO2)2 and R''=H or CH3 have been prepared.The products were characterized by chemical analyses, electrical conductance, IR, 1H NMR, and electronic spectral studies.
Synthesis and characterization of hydrazone and azine derivatives of bis(cyclopentadienyl)zirconium(IV)
Khera, B.,Sharma, A. K.,Kaushik, N. K.
, p. 172 - 174 (2007/10/02)
Pentacoordinated hydrazone and azine derivatives of bis(cyclopentadienyl)zirconium(IV) of the type and , where R = H or CH3 and R' = H, C6H5 or C6H3(NO2)2, have been synthesized by the reaction of bis(cyclopentadienyl)zirconium(IV) dichloride with the appropriate hydrazone or azine in equimolar ratios in refluxing tetrahydrofuran.The products were characterized by chemical analyses, electrical conductance, IR, 1H NMR and electronic spectral studies.
