17744-98-8

Basic information

• Product Name: IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE
• Synonyms: 3-cyanomethylimidazo(1,2-a)pyridine;imidazo(1,2-a)pyridine-3-acetonitrile;IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE;2-(Imidazo[1,2-a]pyridin-3-yl)acetonitrile
• CAS NO: 17744-98-8
• Molecular Formula: C₉H₇N₃
• Molecular Weight: 157.17
• Mol File: 17744-98-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.18g/cm³
• Refractive Index: 1.641
• CAS DataBase Reference: IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE(17744-98-8)
• EPA Substance Registry System: IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE(17744-98-8)

Safety Data

• Hazardous Substances Data: 17744-98-8(Hazardous Substances Data)

Usage

General Description

IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE is a chemical compound belonging to the imidazo[1,2-a]pyridine class. It is also known by the chemical name 3-cyanomidazo[1,2-a]pyridine. IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various pharmaceutical drugs and active ingredients. It is a white to off-white solid, and its molecular structure consists of an imidazopyridine ring fused with a cyanomethyl group. IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE has potential applications in the development of new drugs and also serves as an important intermediate in the production of various chemical compounds.

InChI:InChI=1/C9H7N3/c10-5-4-8-7-11-9-3-1-2-6-12(8)9/h1-3,6-7H,4H2

Upstream product

• 274-76-0 imidazo[1,2-a]pyridine 
• 504-29-0 2-aminopyridine 
• 50-00-0 formaldehyd 
• 2717-95-5 1-(imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine 
• 773837-37-9 sodium cyanide 

Downstream Products

• 1312891-90-9 (E)-3-(4-{[2-(imidazo[1,2-a]pyridin-3-yl)ethylamino]methyl}phenyl)acrylic acid methyl ester 
• 1312891-52-3 (E)-N-hydroxy-3-(4-{[2-(imidazo[1,2-a]pyridin-3-yl)ethylamino]methyl}phenyl)acrylamide 
• 664367-52-6 2-(imidazo[1,2-a]pyridin-3-yl)ethylamine 
• 17745-04-9 imidazo<1,2-a>pyridin-3-acetic acid 
• 950888-59-2 C₉H₁₅N₃ 

Relevant articles and documents

INDOLE AHR INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

New fluorescent heterocyclic systems from imidazo[1,2-a]pyridine: Design, synthesis, spectral studies and quantum-chemical investigations

Two new fluorescent heterocyclic systems dipyrido[1′,2′:1,2]imidazo[4,5-b:4,5-e]pyridine-13-carbonitrile and pyrido[1′,2′:1,2]imidazo[4,5-b]pyrido[2′,1′:2,3]imidazo[4,5-e]pyridine-13-carbonitrile were synthesized by one-pot reaction of imidazo[1,2-a]pyridine with 2-(imidazo[1,2-a]pyridin-3-yl)acetonitrile and 2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile, respectively, in MeOH/KOH solution via the nucleophilic substitution of hydrogen in high yields. Spectral and analytical data have confirmed the structures of the synthesized dyes. The optical and solvatochromic properties of the compounds were investigated and the results showed that they exhibited interesting photophysical properties. Density functional theory (DFT) calculations of fluorescent dyes were performed to provide the optimized geometries and relevant frontier orbitals by using the B3LYP hybrid functional and the 6–311?++ G(d,p) basis set. Calculated electronic absorption spectra were also obtained by time-dependent density functional theory (TD-DFT) method. In addition, electron density iso-surface map, intra- and intermolecular interactions of these fluorescent heterocyclic systems were evaluated by AIM (Atoms in Molecules) analysis.